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Parkinson's disease is a progressive neurodegenerative disorder with multifactorial causes, among which genetic risk factors play a part. The RAB GTPases are regulators and substrates of LRRK2, and variants in the LRRK2 gene are important risk factors for Parkinson's disease. We aimed to explore genetic variability in RAB GTPases within cases of familial Parkinson's disease.
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Emil K. Gustavsson
Jordan Follett
University of Florida
Joanne Trinh
The Lancet Neurology
University of Oxford
Centre National de la Recherche Scientifique
University College London
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Gustavsson et al. (Wed,) studied this question.
synapsesocial.com/papers/68e6f976b6db64358767412c — DOI: https://doi.org/10.1016/s1474-4422(24)00121-2