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You have accessJournal of UrologyProstate Cancer: Detection covariates included age, race, PSA density, clinical stage, PI-RADS score, and biopsy technique. RESULTS: Our final cohort consisted of 369 patients (Table 1). The overall detection rate of csPCa for PI-RADS 3, 4, and 5 lesions was 21%, 47%, and 69%, respectively. Detection of higher grade csPCa on systematic compared to targeted biopsy occurred in 12% of all biopsies. Of these cases, the systematic core detecting higher-grade csPCa was outside of the MRI ROI sextant in 60% and contralateral to the MRI ROI in 16%. Systematic biopsy detected csPCa when the targeted cores were benign in 20/369 cases (5%). There were no identifiable factors associated with detection of higher grade csPCa on systematic biopsy. CONCLUSIONS: Over one in ten patients with a visible MRI lesion have higher grade csPCa detected on systematic biopsy than on targeted biopsy. The majority of these higher-grade systematic cores are detected outside of the ROI sextant; one-sixth are contralateral to the ROI (therefore not attributable to targeting error). Our findings argue against routine omission of systematic biopsy for all patients with MRI lesions. Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1198 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Sean A. Fletcher More articles by this author Mark N. Alshak More articles by this author Yuezhou Jing More articles by this author Nirmish Singla More articles by this author Misop Han More articles by this author Mohamad E. Allaf More articles by this author Christian P. Pavlovich More articles by this author Expand All Advertisement PDF downloadLoading ...
Fletcher et al. (Mon,) studied this question.