White Matter Alterations Evident with DTI, DKI and Axonal Radius Measurements in Clinical Presentation of Chronic Symptomatic mTBI

Diffusion MRI based microstructural evaluation of DTI, DKI, and intra-axonal radii, enabled by the ultra-high performance MAGNUS gradients, was leveraged in this study to assess differences between healthy controls and chronic mild traumatic brain injury presentations. Parcel-wise group and brain WM asymmetry analysis highlighted specific sub-region involvement differing from healthy controls in evaluated metrics. Subject specific analysis highlighted specific anatomical regions that could be more susceptible in TBI with the effect size potentially masked with central tendency analysis.