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In this work, a diffusion preparation was implemented into the 3D spiral-projection MRF sequence to introduce additional diffusion weighting and enables whole-brain T1, T2, PD, ADC and FA mapping with 1-mm isotropic resolution within 10min. To maximize the diffusion signal and image-encoding efficiency, a diffusion-preparation without an amplitude stabilizer is employed, where robustness against phase variations is achieved using a combination of M1-compensated encoding, cardiac-gating, and an eddy-current compensating pre-pulse gradient. The MRF acquisition scheme and subspace reconstruction were also modified to enable effective data sharing across diffusion directions, which increase acceleration capability and improve mapping quality.
Cao et al. (Wed,) studied this question.