Outcomes and Imaging Surveillance Adherence in Juxta-Renal Aortic Aneurysms Repairs: A VASQIP Retrospective Study

Objective: Fenestrated endovascular aortic repair (FEVAR) has demonstrated its value in the management of juxtarenal abdominal aortic aneurysms (JAAA), but data were largely derived from clinical trials and high-volume centers. Although routine imaging surveillance is recommended following endovascular interventions, little is known regarding follow-up compliance post-FEVAR. We examined the real-world treatment outcomes and adherence to the postoperative follow-up protocol after elective interventions for JAAA at Veteran Affairs (VA) health care facilities, the largest integrated health care system in the United State. Methods: This is a retrospective cohort study. We queried the Veteran Affairs Surgical Quality Improvement Program (VASQIP) database for elective FEVARs and juxtarenal open surgical repairs (j-OSR), then merged follow-up imaging and mortality information. Our primary endpoints were mortality following FEVAR and j-OSR, and adherence to surveillance guidelines. Secondary endpoints included short-term postoperative complications. Results: A total of 1110 veterans who underwent first-time JAAA repair between 2002 and 2019 (FEVAR, 26% n=290; j-OSR, 74% n=820) were included in the analysis. The number of j-OSR captured in the database gradually declined by 50%, from 62 interventions in 2002 to 28 in 2019, while FEVAR procedures quadrupled from 20 procedures in 2014 to 94 in 2019. The median follow-up was 3.99 years (95% confidence interval CI: 3.73-4.87) for FEVAR patients, and 12.80 (12.31-13.70) for those that underwent jOSR. A significantly lower risk of 30-day mortality was observed following FEVAR compared to j-OSR (1% vs 5%, odds ratio OR: 5.03 1.54-16.38; p=0.003). At 5 years, FEVAR was linked with significantly higher mortality (41.5% vs 21%, p<0.001) after adjusting for confounders (aHR=2.10 1.56-2.82, p<0.001). Of surviving patients, the follow-up imaging rate was 66.3% by 1-year post-FEVAR. Follow-up rate at 5 years was 7% post-FEVAR compared to 32% post j-OSR. Conclusion: Elective FEVAR is associated with lower perioperative mortality and morbidities compared to elective j-OSR for juxtarenal aortic aneurysms. However, the perioperative survival benefits of FEVAR diminish over time, with its mortality surpassing that of j-OSR at longer follow-up periods. The compliance with post-FEVAR imaging surveillance is also low. Further research is warranted to develop strategies to improve adherence to imaging surveillance protocols. Clinical Impact This study provides real-world evidence on the outcomes and follow-up adherence following fenestrated endovascular aortic repair (FEVAR) for juxtarenal abdominal aortic aneurysms (JAAA) in the Veterans Affairs health care system. With FEVAR’s increasing use, the findings highlight the need for improved surveillance protocols, as adherence to postoperative imaging declines significantly after the first year. Clinicians should be aware of the risk of long-term mortality despite FEVAR’s short-term benefits, urging better follow-up strategies that relay a survival benefit for patients.