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Nonoperative Management of Mismatch Repair–Deficient Tumors | Synapse

April 27, 2025Open Access

Nonoperative Management of Mismatch Repair–Deficient Tumors

Key Points

To assess the impact of neoadjuvant PD-1 blockade on organ preservation in mismatch repair-deficient tumors.
Evaluated early-stage dMMR solid tumors
Administered neoadjuvant PD-1 blockade before curative-intent surgery
High proportion of patients experienced organ preservation
Effective intervention for managing dMMR tumors without surgery

Abstract

Among patients with early-stage dMMR solid tumors that were amenable to curative-intent surgery, neoadjuvant PD-1 blockade led to organ preservation in a high proportion of patients. (Funded by Swim Across America and others; ClinicalTrials.gov number, NCT04165772.).

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Authors

A

Andrea Cercek

M

Michael B. Foote

B

Benoı̂t Rousseau

Journals

New England Journal of Medicine

Actions

Institutions

Memorial Sloan Kettering Cancer Center

Cancer Institute (WIA)

Hartford Financial Services (United States)

References and Citations

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Cite this study

Cercek et al. (Sun,) studied this question.

www.synapsesocial.com/papers/6941d25ca0e04400c528bde9 — DOI: https://doi.org/10.1056/nejmoa2404512