Supplementary Figure 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer

Key Points

• Main finding demonstrates that ISR pathway inhibition impacts multiple immune checkpoints in lung cancer.
• Key evidence includes in vitro and in vivo data showing effects of ISR inhibition on cancer cell behavior.
• Approach involved examining the integrated stress response in relation to immune checkpoints using various models.
• Significance lies in its potential to inform new treatment strategies for lung cancer by targeting the ISR pathway.