Novel Indole‐Linked 1,2,3‐Triazole Analogues: Synthesis, Anti‐Tubercular Screening, and Molecular Docking Analysis

ABSTRACT The design and synthesis of novel indole‐linked 1,2,3‐triazole hybrids targeting Mycobacterium tuberculosis (H37Rv). The methods are summarized, highlighting the use of CuAAC reactions for synthesis and characterization via HRMS, NMR, and in vitro anti‐tubercular screening. Key results emphasize the potent activity of para ‐nitro and cyano‐substituted compounds (MIC = 1.56–3.125 μg/mL), comparable to ethambutol, supported by molecular docking studies revealing strong binding interactions with MtbAT protein. The significance of these findings is underscored by their potential to address drug‐resistant TB, with ADMET profiles suggesting promising drug‐like properties.