Motivation: Fibrosis of the infrapatellar fat pad (IPFP) impacts knee osteoarthritis (KOA) progression 1. Accurate assessment of IPFP fibrosis aids early intervention and treatment. Goal(s): To evaluate the diagnostic efficacy of proton density fat fraction (PDFF) and T2* measurements using mDixon-Quant technology in assessing IPFP fibrosis in KOA. Approach: We employed mDixon-Quant sequence to measure PDFF and T2*of IPFP, and evaluated correlations of the parameters with pathology-derived IPFP fibrosis degree and diagnostic efficacy. Results: PDFF and T2* measurements were strongly correlated with IPFP fibrosis and showed good diagnostic performance for IPFP fibrosis. Impact: PDFF and T2* measurements based on mDixon technology provide a non-invasive and quantitative assessment of IPFP fibrosis, especially PDFF.
Zhou et al. (Tue,) studied this question.