Abstract This review examines the health benefits, market potential, and sustainability of A2 milk products derived from cattle with the A2A2 β-casein genotype, highlighting their role as a tool in rural transformation, particularly in the Global South, where integrated perspectives on nutritional innovation and socioeconomic development remain underexplored. By addressing this knowledge gap, this synthesis combines current scientific evidence, market data, and policy discussions to examine the biochemical basis of A2 milk, its health benefits, and the socioeconomic opportunities associated with promoting its production through sustainable, rural-based livestock systems. The global A2 milk market, valued at USD 4.0 billion in 2024, is projected to grow at an annual rate of 18.5% through 2030, driven by rising health consciousness and consumer willingness to pay premium prices for high-value agricultural (HVA) products. Indigenous cattle breeds with naturally high frequencies of the A2A2 genotype offer sustainable production pathways while supporting genetic conservation, and non-bovine species such as water buffaloes exhibit exclusive A2A2 homozygosity, making all buffalo milk naturally A2, while goats and sheep show higher A2 allele frequencies compared to cattle, positioning them as safer alternatives with lower β-casomorphin release potential. Small-scale dairy farming systems, especially those organized through cooperatives, present opportunities to enhance rural livelihood through premium pricing for HVA products such as A2 milk. However, scientific validation, regulatory standardization, and supply chain segregation remain. Limited clinical trials and inconsistent certification frameworks continue to constrain broader market expansion. This review presents A2 milk as a convergence point of nutritional innovation and rural development, emphasizing value-added products, niche market segments, and the potential of indigenous cattle, non-bovine species, and cooperative models in scaling sustainable dairy production.
Priyashantha et al. (Tue,) studied this question.