Supplementary Figure S4 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Key Points

• Scar-like cases in bladder cancer show improved clinical outcomes after neoadjuvant therapy, highlighting their favorable prognosis.
• Of the thirteen identified scar-like cases, twelve showed stroma-rich characteristics, indicating distinct pathophysiology.
• Evidence about clinical outcomes is linked directly to the presence of stroma-rich tumors classified by a consensus subtyping model.
• Understanding these transcriptomic profiles could lead to better therapeutic strategies for patients treated with pembrolizumab.