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Abstract Aims Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive‐age women, associated with insulin resistance, hyperandrogenism, and menstrual irregularities. Nutraceutical interventions—bioactive compounds derived from foods or supplements that provide health benefits beyond basic nutrition—may support conventional therapy. This study aimed to systematically evaluate the effects of nutraceutical interventions on reproductive and metabolic outcomes in PCOS. Materials and Methods This systematic review and meta‐analysis was registered in PROSPERO (CRD42024521879) and followed PRISMA 2020. Searches were performed in PubMed, Embase, Cochrane Library, Web of Science, and regional databases (January 2013–December 2024) and included 78 eligible studies. Eligible randomized and quasi‐experimental studies assessed nutraceuticals such as vitamin D, inositol, and quercetin. Risk of bias was evaluated with standardized tools; certainty of evidence was graded by GRADE. Results Seventy‐eight studies met inclusion criteria. Nutraceutical interventions significantly reduced fasting insulin (MD = −2.14 μIU/mL; 95% CI –3.12 to −1.16) and luteinizing hormone (MD = −1.34 mIU/mL; 95% CI –2.10 to −0.58) and increased sex‐hormone‐binding globulin (MD = +3.72 nmol/L; 95% CI 1.35 to 6.09). Vitamin D supplementation showed the strongest metabolic and hormonal improvements. Results for ovarian follicle count and menstrual bleeding were inconsistent. Conclusions Nutraceutical interventions targeting metabolic and hormonal regulation may complement lifestyle therapy in women with PCOS. Interpretation is limited by study heterogeneity and variable methodological quality. No external funding was received.
Çelik et al. (Mon,) studied this question.