What question did this study set out to answer?

To develop a NIR light-activated gene editing system utilizing CRISPR technology for precise gene regulation.

January 6, 2026Open Access

Near infrared light controlled gene editing

Key Points

To develop a NIR light-activated gene editing system utilizing CRISPR technology for precise gene regulation.
Implemented a CRISPR-dCas9/Cas9 system activated by near infrared light.
Utilized a chemically cleavable rapamycin dimer for control of gene editing actions.
Assessed the responsiveness and efficiency of the system in living organisms.
Achieved precise and rapid gene regulation under NIR light.
Demonstrated deeper tissue penetration compared to previous systems.
Showed low toxicity and minimal background activity, enhancing overall safety.

Abstract

Abstract A novel NIR light-activated CRISPR-dCas9/Cas9 system achieves precise and rapid gene regulation in living organism using a chemically cleavable rapamycin dimer. Unlike previous light-driven systems, this approach offers deeper tissue penetration, low toxicity, fast response, and minimal background activity. This platform opens new directions for highly efficient, targeted, noninvasive, and spatially confined gene editing for a great number of preclinical and clinically translatable applications.

Near infrared light controlled gene editing

Key Points

Abstract

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