Indazoles and benzisoxazoles, two eminent nitrogen‐containing heterocyclic scaffolds, have attracted tremendous attention for diverse biological activities, involving antibacterial, anticancer, antiviral, antitumor, and antibiotic studies. On the other hand, a proficient tool for inserting, exchanging, or deleting atom within the core structure of the molecules, is described as skeletal editing, which is also a hot topic in recent days. Therefore, the skeletal modification of N ‐heterocycles facilitates many challenging synthetic pathways into simplified synthetic strategies for several medicinally important biochemicals. In general, the skeletal editing of these heterocycles proceeds through carbon insertion, nitrogen insertion and C−N bond insertion. This review article provides an overview of an eminent synthetic strategy, skeletal editing, of two noteworthy widespread heterocyclic compounds with literature coverage up to June, 2025.
Ghosh et al. (Sat,) studied this question.