A Review on the Synthesis of Biologically Active Thiazoles

Abstract: Heterocycles have attracted the attention of researchers for a long time due to their applications in various fields. S- and N-containing heterocyclic compounds have a significant impact in organic chemistry. They are important not only industrially and biologically but also in the development of human society. Thiazoles are essential components in medicinal chemistry as well as key structural elements in many naturally occurring substances. Because of their notable biological properties, thiazoles have been an interesting topic of research, and many drugs have been designed that possess the thiazole moiety. As a result, the development of innovative techniques for synthesizing these molecules remains highly interesting. Many methodologies have been developed for the preparation of thiazoles, and the emergence of novel, environmentally friendly synthetic approaches is highly desirable. The present review article provides an overview of the biological importance and synthetic methods for the formation of thiazoles, promoting further research on the development of thiazole-containing drugs. It encourages researchers to synthesize novel and potent thiazoles effective against mutant strains, and the development of synthetic protocols is a high priority in medicinal chemistry research. This review will help to advance the search for strategies for the synthesis of biologically active thiazoles.