Metastasis-directed therapy and standard of care versus standard of care for oligometastatic prostate cancer (WOLVERINE): a systematic review and individual patient data meta-analysis from the X-MET collaboration

Key Points

• Improved outcomes are associated with metastasis-directed therapy in oligometastatic prostate cancer.
• The systematic review analyzed individual patient data from the X-MET collaboration with 150 studies involved.
• Observational analysis focused on the effectiveness of combining metastasis-directed therapy with standard care.
• These findings may influence treatment guidelines, but further validation in diverse populations is needed.