Higher levels of NT-proBNP were associated with a 2.35 ml/min/1.73m2 lower eGFR (per 1 SD increase) and a 1.81-fold higher odds of prevalent CKD cross-sectionally, and with a 1.37 ml/min/1.73m2 faster 10-year eGFR decline and 1.39-fold higher risk of incident CKD longitudinally in a European general adult population.
Observational
Yes
Are elevated levels of myocardial stress markers (MR-proADM, MR-proANP, NT-proBNP) associated with reduced kidney function and higher prevalence/incidence of chronic kidney disease in the general population?
61,830 participants from the general European population (BiomarCaRE project), mean age 51.8 years, 52.1% female. Longitudinal analysis included 4,205 individuals.
Elevated levels of myocardial stress markers: mid-regional pro-adrenomedullin (MR-proADM), MR-pro-atrial natriuretic peptide (MR-proANP), and N-terminal pro-B-type natriuretic peptide (NT-proBNP)
Lower levels of the same myocardial stress markers (e.g., lowest group/quartile or per 1 standard deviation decrease)
Kidney function assessed by estimated glomerular filtration rate (eGFR) and prevalence/incidence of chronic kidney disease (CKD, defined as eGFR < 60 ml/min/1.73m2)surrogate
Higher levels of myocardial stress markers (MR-proADM, MR-proANP, and NT-proBNP) are significantly associated with lower kidney function and higher prevalence and incidence of chronic kidney disease in the general population.
Abstract Given the complex relationship between cardiovascular disease (CVD) and chronic kidney disease (CKD), CVD-related markers may serve as CKD biomarkers. We examined associations of three major CVD-markers mid-regional pro-adrenomedullin (MR-proADM), MR-pro-atrial natriuretic peptide (MR-proANP), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) with CKD. Cross-sectional analyses included up to 61,830 participants, and longitudinal analyses (NT-proBNP only) 4205 individuals. Kidney function was assessed by estimated glomerular filtration rate (eGFR) using creatinine, cystatin C, or both (eGFRcr-cys). Markers were categorized into four groups. Cross-sectional analyses found that higher levels of all three markers were consistently associated with lower eGFR and higher CKD prevalence. For example, per 1 standard deviation (SD) increase in log-transformed NT-proBNP, corresponding to a 2.71-fold increase in the original concentration, was associated with -2.35 (-2.49, -2.21) ml/min/1.73m 2 lower eGFRcr-cys, and the highest NT-proBNP group had a 5.72-fold higher odds of CKDcr-cys (eGFRcr-cys < 60 ml/min/1.73m 2 ) compared with the lowest. Associations with eGFR were stronger among participants with CVD and diabetes. In longitudinal analyses, participants with higher baseline NT-proBNP had faster declines in eGFR, with a 10-year decline of -1.37 (-1.77, -0.98) ml/min/1.73m 2 eGFRcr-cys per 1 SD increase, and higher CKD incidence. These findings suggest MR-proADM, MR-proANP, and NT-proBNP as CKD biomarkers.
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Jie-sheng Lin
Tanja Zeller
Wolfgang Koenig
Scientific Reports
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Lin et al. (Mon,) conducted a observational in General adult population from Europe with variable cardiovascular disease and diabetes status, assessed for kidney function and chronic kidney disease (n=61,830). Higher levels of myocardial stress markers (NT-proBNP, MR-proANP, MR-proADM) vs. Lower levels of these markers (group 1) was evaluated on Kidney function measured by estimated glomerular filtration rate (eGFRcr-cys) and prevalence/incidence of chronic kidney disease (CKDcr-cys defined as eGFR < 60 ml/min/1.73m2) (Cross-sectional: For each 1 SD increase in log-transformed NT-proBNP, eGFRcr-cys decreased by 2.35 ml/min/1.73m2; Odds ratio (OR) for prevalent CKDcr-cys was 1.81 (95% CI 1.72–1.90); Highest NT-proBNP group (≥300 pg/ml) had OR 5.72 (95% CI 4.82–6.78) vs lowest group (<48 pg/ml). Longitudinal: For each 1 SD increase in log-transformed NT-proBNP, 10-year decline in eGFRcr-cys was –1.37 ml/min/1.73m2 (95% CI –1.77 to –0.98); Hazard ratio (HR) for incident CKDcr-cys was 1.39 (95% CI 1.20–1.62); Highest NT-proBNP group had HR 4.40 (95% CI 2.63–7.36) vs lowest group., 95% CI As stated above., p=All associations statistically significant with p<0.05, many p<0.001). Higher levels of NT-proBNP were associated with a 2.35 ml/min/1.73m2 lower eGFR (per 1 SD increase) and a 1.81-fold higher odds of prevalent CKD cross-sectionally, and with a 1.37 ml/min/1.73m2 faster 10-year eGFR decline and 1.39-fold higher risk of incident CKD longitudinally in a European general adult population.
www.synapsesocial.com/papers/699d3fc8de8e28729cf647a7 — DOI: https://doi.org/10.1038/s41598-026-37377-2
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