What question did this study set out to answer?

To examine the protective effects of memantine hydrochloride on cognitive deficits caused by radiation.

March 12, 2026

Protective effect of memantine hydrochloride on radiation-induced cognitive impairment and its mechanism

Key Points

To examine the protective effects of memantine hydrochloride on cognitive deficits caused by radiation.
Investigated the impact of memantine on cognitive deficits due to radiation exposure.
Analyzed effects on synaptic signaling, nitrosative stress, and Aβ42 accumulation.
Generated hypotheses for further mechanistic studies.
Memantine mitigated acute cognitive deficits associated with radiation.
Modulation of synaptic signaling was observed as a proposed mechanism.
Suppression of nitrosative stress and reduction of Aβ42 accumulation were noted.

Abstract

Memantine hydrochloride attenuates acute radiation-related cognitive deficits, potentially via modulation of synaptic signaling and suppression of nitrosative stress and Aβ42 accumulation. Findings will be interpreted as generating hypotheses that motivate subsequent mechanistic experiments and preliminary translational work.

اسأل الذكاء الاصطناعي

Bookmark

Cite This Study

Wang et al. (Mon,) studied this question.

synapsesocial.com/papers/69b257fc96eeacc4fcec7239 https://doi.org/https://doi.org/10.1097/hp.0000000000002112

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

اسأل الذكاء الاصطناعي

Bookmark