Research Progress on Pyrazine-based Medicinally Active Compounds: A Review

Medicinal chemists are highly interested in pyrazine-based compounds due to their diverse biological roles and potential therapeutic applications for various disorders. This research examines the expansion of pyrazine-derived compounds between the years 2014 and 2025. This review emphasizes their established efficacy against Cancer, Tuberculosis, Alzheimer's disease, microbial infections, inflammation, and viral pathogens. Pyrazines have shown significant prospects for drug discovery caused by their ability to target several biological processes. This paves the way for novel therapies. We have discussed significant discoveries of pyrazines, their complex mechanisms, and the necessary future actions to enhance the utility of pyrazine-based compounds as pharmaceuticals.