细胞骨架调控溶酶体动态与功能

Key Points

• Investigate how the cytoskeleton regulates lysosomal dynamics and function in cellular processes.
• Detailed description of the roles of microtubules and microfilaments in lysosomal transport.
• Exploration of molecular mechanisms involved in lysosomal positioning and fusion with other organelles.
• Discussion on pathological implications related to cytoskeleton-lysosome dysfunction.
• Microtubules facilitate the bidirectional transport of lysosomes between the cell membrane and nucleus.
• Microfilaments support short-range transport and positioning of lysosomes, enabling interactions with other cellular structures.
• Dysfunction in the cytoskeleton-lysosome axis is linked to neurodegenerative diseases and tumors.

Abstract