Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome

Key Points

• This study aims to investigate how disruptions in circadian rhythms affect cognitive impairment and dementia symptoms in adults with Down syndrome who have Alzheimer disease.
• Examined the association of 24-hour rest-activity rhythms with cognitive performance and dementia symptoms.
• Assessed clinical Alzheimer disease status in the population of adults with Down syndrome.
• Found a significant association between disrupted circadian rhythms and worsening cognitive function in adults with Down syndrome.
• Identified correlations between rest-activity rhythm patterns and severity of dementia symptoms.