Background The gallbladder plays an essential role in lipid homeostasis through bile storage and regulated release. Gallstone disease is frequently associated with dyslipidemia, and cholecystectomy is one of the most common abdominal surgeries worldwide. However, its influence on serum lipid metabolism remains incompletely understood. Objective To evaluate changes in serum lipid profiles six months after cholecystectomy and assess whether the procedure has any adverse effect on lipid metabolism. Methods A prospective, single-arm, before-after study was conducted on 40 adult patients undergoing laparoscopic cholecystectomy for symptomatic gallstone disease between August 2022 and March 2023. Fasting lipid profiles—including LDL-cholesterol, HDL-cholesterol, triglycerides, total cholesterol, and VLDL—were measured preoperatively and at 6-month follow-up. The Atherogenic Index of Plasma (AIP) and total cholesterol/HDL ratio were calculated. Statistical analysis was performed using paired tests with significance set at p
Alatrash et al. (Wed,) studied this question.