ESC 2026 DiscussionExplore the Hot Line trials, expert perspectives, and key takeawaysExplore the discussion→Papers from every journal, all in one place. Create custom feeds.
Mandates heritage-specific screening and interventions for Hispanic adults; challenges the Hispanic paradox as an oversimplification requiring disaggregated data.

Supports semaglutide use across frailty levels in CVD; extends SELECT benefits to frail subgroups without heterogeneity.

What was less expected was that persons with frailty appeared to derive greater benefits on how they felt and functioned (eg, mobility appeared to improve more with semaglutide in persons with frailty); and that, compared with placebo, persons with greater frailty were actually less likely to dis...
Correspondence response addresses inquiries regarding dapagliflozin for recurrence after catheter ablation, highlighting methodological considerations.

Cardiovascular electrophysiology fellow, Beijing Anzhen Hospital
It is not a problem to use dapagliflozin, but we did not see any effect on early recurrence of AFib. However, we remain very confident about its potential, given that a considerable proportion of patients with atrial fibrillation also have heart failure, particularly heart failure with preserved ejection fraction. We believe that a larger, placebo-controlled trial with an extended follow-up period is warranted to more comprehensively evaluate its potential antiarrhythmic benefits.
Video-based education matches nurse-guided pamphlets for home BP skills in stage 3–4 CKD; supports equivalent efficacy of scalable digital versus traditional education.

DUTCH-WAIST will test semaglutide for rhythm control in overweight persistent AF; leaves open whether GLP-1 RAs improve arrhythmia outcomes pending RCT results.

May warrant closer monitoring in elderly patients with vaccine myocarditis; hypothesis-generating and requires prospective confirmation.

Minicrush was associated with lower stent thrombosis than TAP without differing target lesion failure; leaves open need for randomized confirmation in bifurcation PCI.

Correspondence analyzes early recurrence outcomes after catheter ablation for atrial fibrillation with dapagliflozin, highlighting key methodological considerations in trial interpretation.

Clinicians should assess digital literacy and offer guided resources; leaves open development of evidence-based guidelines for heart failure digital tools.

Modest sensitivity, low PPV, and demographic biases caution against clinical use; leaves open whether complex ML outperforms simpler regression for hypertension case-finding.
