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Meta-analysis reveals improved coronary flow following intracoronary low-dose thrombolysis during primary PCI in STEMI, indicating therapeutic benefit without major bleeding.
Interventional Cardiologist, University of Alberta
In this contemporary meta-analysis of 4 randomized controlled trials, adjunctive intracoronary low-dose thrombolysis during primary PCI does not improve epicardial flow, myocardial perfusion, or clinical outcomes. Current evidence does not support its routine use, and this strategy should be considered contraindicated (class III) in contemporary practice.
LA strain identifies higher-risk ATTR-CM patients; extends vutrisiran benefits to slowing atrial myopathy.
Injectable antiplatelets may enable rapid inhibition in unstable STEMI; leaves open randomized trials in shock and arrest.
CKM staging tracks with CV health and carotid metrics in young adults; leaves open whether staging improves long-term risk prediction.
Cardiologist, Boston Medical Center
The study shows that CKM syndrome staging and Life's Essential 8 are complementary for identifying adults younger than age 30 who may be on the fast track for arterial injury, plaque build-up and, ultimately, at higher risk for future cardiovascular events.
AI models show predictive promise for perioperative complications; leaves open routine use pending external validation and impact trials.
Subgroup findings in birisk diabetic ACS patients may support extended clopidogrel monotherapy; leaves open confirmation in dedicated trials.
Underrepresentation hinders variant interpretation and SCD care in African-descent patients; leaves open inclusive genomic studies to close equity gaps.
Endocardial PFA yields durable transmural mitral isthmus block in only ~52% of cases; leaves open the role of adjunctive strategies in AF ablation.
May aid early pericarditis screening via fused clinical-ECG data; leaves open prospective validation before clinical use.
Cardiologist, Cardiology Department, A.O.U. Città della Salute e della Scienza di Torino
In 6508 patients, including 902 with clinically confirmed pericarditis, the fused model outperformed either component alone, with an area under the receiver operating characteristic curve of 0.89 compared with 0.85 for the ECG model and 0.74 for the tabular model. At the selected threshold, the negative predictive value was 0.96, although the positive predictive value remained 0.48.
Evidence gaps hinder post-retirement cardiometabolic care; leaves open inclusive longitudinal studies.