Does Transcatheter Tricuspid Valve Replacement (TTVR) improve safety and effectiveness at 30 days in real-world patients with severe TR?

Result: Thirty-day outcomes demonstrated acceptable safety, near-complete TR elimination, and significant health status improvements, with lower rates of new CIED implantation and bleeding than in randomized trials.

How do safety and clinical outcomes compare between transcatheter tricuspid edge-to-edge repair and transcatheter tricuspid valve replacement in patients with severe tricuspid regurgitation?

Result: T-TEER was associated with very low in-hospital (0.13%) and 30-day (0.46%) mortality, whereas TTVR had higher early mortality but similar 1-year mortality, achieved more complete TR elimination, but had higher rates of permanent pacemaker implantation, thrombotic events, and major bleeding.

Result: Emergent coronary angiography and intracoronary imaging identified severe mid-RCA stenosis associated with a calcified nodule with an overlying thrombus, and a positive acetylcholine provocation test confirmed coronary spastic angina.

Does whole-exome sequencing identify clinically relevant genetic variants in young and middle-aged adults with pre-hospital sudden cardiac arrest?

Result: Pathogenic or likely pathogenic variants were identified in 13 individuals, corresponding to a diagnostic yield of 18.8%.

Does bioprosthetic mitral valve replacement increase the incidence of infective endocarditis compared to mitral valve repair in patients undergoing mitral valve intervention?

Result: Infective endocarditis was significantly more common after surgical MV replacement than surgical MV repair (IRR 2.34, 95% CI 1.06-5.18, p=0.035), but not significantly different between transcatheter MV replacement and repair (IRR 1.56, 95% CI 0.73-3.34, p=0.250).

Result: The paper provides a detailed historical consideration of the medical literature from 1800 to trace the provenance and evolving understanding of spontaneous coronary artery dissection.

Does hypertrophic cardiomyopathy increase the risk of infective endocarditis compared to matched controls?

Result: The 5-year cumulative incidence of IE was 3.25% in the HCM group and 1.31% in controls (HR 2.62, 95% CI 2.20 to 3.12, p<0.001).

Does postmortem genetic testing identify pathogenic variants in Sudden Arrhythmic Death Syndrome cases?

Result: Postmortem genetic testing identifies pathogenic or likely pathogenic variants in a significant subset of SADS cases.

Does endovascular therapy improve post-thrombotic syndrome severity and health-related quality of life in patients with moderate or severe post-thrombotic syndrome and iliac-vein obstruction?

Result: Endovascular therapy led to less severe post-thrombotic syndrome and better health-related quality of life than standard care over a 6-month period, but with a higher risk of bleeding.

Do employer-sponsored workplace wellness programs reduce cardiovascular disease risk factors in at-risk civilian adults?

Result: Most studies reported non-statistically significant results for CVD risk factors, but nearly half found significant improvements in systolic blood pressure.