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RCT · n=7847 mentionsTrending on XTrending on X
JUL 30Oosterom-EijmaelJAMA
Dapagliflozin before elective cardiac surgery reduces 7-day AKI ~46% versus placebo.
Perioperative dapagliflozin reduces postoperative AKI; extends SGLT2i use to cardiac surgery prevention.
DWDr. Wolfgang C. Winkelmayer
nephrologist, Baylor College of Medicine
Hereon, investigators should aim to better understand the mechanism(s) by which SGLT2 inhibitors reduce the risk of AKI among patients undergoing elective cardiac surgery as well as those with type 2 diabetes, heart failure, and chronic kidney disease treated with SGLT2 inhibitors longer-term. Moreover, they should briskly and rigorously conduct randomized, placebo-controlled clinical trials of SGLT2 inhibitors in established AKI, aiming to arrest or attenuate its evolution and/or hasten its recovery.
systematic_review · n=52,0002 mentions
JUL 31FanousEuropean Heart Journal - Quality of Care and Clinical Outcomes
Digital and workflow interventions boost 1-year AVR rates by ~30% and shorten TAVI wait times.
Persistent severe AS pathway delays warrant targeted workflow reforms now; extends evidence base for digital and organizational interventions.
RCT · n=2796 mentions
JUL 30PüntmannNature Communications
Losartan plus prednisolone fails to improve LVEF over placebo in post-COVID syndrome.
First RCT of anti-inflammatory therapy in post-COVID cardiac involvement; leaves open whether losartan plus prednisolone improves symptoms or imaging.
ARAnonymous Reviewer
Peer Reviewer, Springer Nature
The manuscript is well written, the introduction and aim are easy to follow, and the results are somewhat easy to follow. Notwithstanding, this reviewer is somewhat uneasy about the presentation of the changes in anatomical and functional measurements.
cohort · n=271,4961 mentions
JUL 31DeringtonUniversity of Pennsylvania
One-year BP control among Veterans remains largely unchanged despite 2017 target-lowering guidelines and the pandemic.
Low BP control persisted after 2017 guideline and during COVID; leaves open how to overcome therapeutic inertia in incident hypertension.
systematic_review · n=108 mentionsTrending on X
JUL 30RamzyCureus
GLP-1 RAs linked to lower incident AF and post-ablation recurrence based on low-confidence evidence.
Cautions against over-relying on overlapping low-confidence meta-analyses; leaves open need for independent high-quality trials on GLP-1 RAs and AF.
DLDr. Lee
Clinical Pharmacy, PlexusDx
Semaglutide is not absolutely contraindicated in atrial fibrillation, but individual cardiac history, current medications, and AFib severity must guide the decision. Recent data shows GLP-1 receptor agonists may offer cardiovascular benefits in certain patient populations, yet AFib presents unique arrhythmia-specific considerations that require personalized evaluation.
Human Clinical Trial2 mentionsTrending on X
AUG 3PackHeart
Pharmacological blood pressure lowering reduced cardiovascular death and HF hospitalisation (RR 0.86; 95% CI 0.83-0.89; p≤0.001), but benefits were not associated with the degree of BP reduction.
BP lowering shows no outcome benefit in HFmrEF/HFpEF; leaves open whether it mediates therapy effects or warrants targeted trials.
cohort · n=1573 mentionsTrending on X
AUG 1MatsumotoJournal of Cardiovascular Electrophysiology
LLM-based framework matches CNN performance for localizing PVC origins from 12-lead ECGs.
May support interpretable ECG analysis for PVC localization; leaves open prospective validation before clinical use.
cohort · n=2,4431 mentions
JUL 31AnJournal of the American Heart Association
Young men with high blood pressure are diagnosed ~36% less often and later than women.
Diagnostic delays may occur in young adults with high BP, especially men; leaves open whether targeted screening improves timely diagnosis.
RCT · n=1291 mentionsTrending on X
AUG 1SattarFuture Cardiology
Center-based cardiac rehab achieves superior gains in exercise capacity and blood pressure control versus home-based.
Home-based CR may expand access without loss of benefit; extends RCT evidence to Iranian settings.
meta-analysis · n=11,1041 mentions
JUL 31QiaoAlzheimer s & Dementia
Each 10% increase in systolic BP variation is linked to faster annual cognitive decline.
May warrant cognitive monitoring in high-variability patients; leaves open whether reducing variability slows decline.
