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From Caging to Uncaging With Bioadaptors: A Novel Paradigm in Coronary Revascularization
Does the DynamX coronary bioadaptor improve clinical outcomes and restore vessel function compared to conventional drug-eluting stents in patients with coronary artery disease?
Result: The DynamX coronary bioadaptor demonstrated noninferiority to drug-eluting stents with superior late lumen preservation, reduced neointimal hyperplasia, and low target-lesion failure rates, while restoring vessel pulsatility and compliance after 6 months.
“From Caging to Uncaging With Bioadaptors: A Novel Paradigm in Coronary Revascularization | Journal of the American Heart Association https://t.co/umPCKN5822”
Effect of high-intensity interval training on peak oxygen uptake, quality of life, and ventricular arrhythmias in patients with an implantable cardioverter defibrillator: a randomized controlled trial
Randomized controlled trial shows HIIT improves exercise capacity and quality of life in ICD patients, indicating potential benefits.
Contribution of Non-Sustained Ventricular Tachycardia to the Primary Prevention of Sudden Cardiac Death ― Validation of Current Japanese Circulation Society / Japanese Heart Rhythm Society Guideline Recommendations in the Nippon Storm Study ―
Does non-sustained ventricular tachycardia (NSVT) predict sudden cardiac death in Japanese patients receiving ICDs for primary prevention?
This study aims to validate the prognostic significance of non-sustained ventricular tachycardia in Japanese patients receiving ICDs for primary prevention.
“A history of NSVT showed limited prognostic value for primary prevention ICD therapy. Holter-documented NSVT modestly predicted appropriate ICD therapy but was not associated with VF or mortality. By Ryobun Yasuoka https://t.co/DB7T6avwKb #circ_j #CardioX https://t.co/JJIixfQYXM”
Plasma Protein Profiles in Different Heart Failure Phenotypes
Are specific plasma protein profiles associated with incident heart failure across different preceding phenotypes (MI, AF, or neither)?
Result: 60 proteins were significantly associated with incident HF across all three groups, with LRRN1 inversely associated (HR 0.49-0.58) and ADM strongly positively associated (HR 5.19-7.78 in MI-HF and AF-HF).
Heart Failure Guideline-Directed Medical Therapy Scoring Systems: A Scoping Review
Result: Key gaps in GDMT scores include heterogeneous weighting of drug classes and doses, minimal incorporation of intolerance to identify maximum-tolerated therapy, and heterogeneous incorporation of therapies beyond quadruple therapy.
“Heart Failure Guideline-Directed Medical Therapy Scoring Systems: A Scoping Review Multiple, disparate scores have been developed to quantify heart failure with reduced ejection fraction GDMT optimization, undermining the original intent. Key gaps in scores include heterogeneous https://t.co/mmJrpNC96G”
Mycn Reactivates the Cell Cycle in Adult Cardiomyocytes and Promotes Cardioprotection in Myocardial Infarction
Result: Mycn reactivates the cardiomyocyte cell cycle and promotes cardioprotection following ischemic injury, likely via induction of a neonatal-like transcriptional program.
Real-World Outcomes of Transcatheter Tricuspid Valve Replacement
Early real-world experience with TTVR shows effective outcomes in severe tricuspid regurgitation, indicating safety benefits.
“Good performance of EVOQUE valve in this STS/ACC TVT Registry of Real-World Outcomes of Transcatheter Tricuspid Valve Replacement with >98% success but 16% new CIED w/o impact on 30 days outcomes. https://t.co/zipqHU6ho5”
These findings show that transcatheter tricuspid valve replacement is translating well from the clinical trial setting into routine practice across the United States. In a large, older and medically complex patient population, we saw very high procedural success, near-complete elimination of tricuspid regurgitation, and rapid improvement in how patients feel and function.
Risk factor profiles and haemodynamic progression in aortic stenosis: a retrospective population-based study
Result: Rapid progression occurred in 7.8% of patients with aortic sclerosis, 16.4% with mild AS and 29.8% with moderate AS.
Incidence of Infective Endocarditis Following Surgical or Transcatheter Mitral Valve Repair or Replacement: A Systematic Review and Meta-Analysis
Does bioprosthetic mitral valve replacement increase the incidence of infective endocarditis compared to mitral valve repair in patients undergoing mitral valve intervention?
Result: Infective endocarditis was significantly more common after surgical MV replacement than surgical MV repair (IRR 2.34, 95% CI 1.06-5.18, p=0.035), but not significantly different between transcatheter MV replacement and repair (IRR 1.56, 95% CI 0.73-3.34, p=0.250).
On the provenance of spontaneous coronary artery dissection
Result: The paper provides a detailed historical consideration of the medical literature from 1800 to trace the provenance and evolving understanding of spontaneous coronary artery dissection.