Ask Anything

Paul M. Ridker

Director, Center for Cardiovascular Disease Prevention, Mass General Brigham · Mass General Brigham / Harvard Medical School

15h

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Given our neutral findings, one logical next step is to move upstream, instead of downstream, to find the right target. For example, there are multiple new agents in development that can inhibit the upstream NLRP3 inflammasome. At the same time, it remains quite possible that downstream IL-6 inhibition is in fact effective, but that ZEUS targeted the wrong patient population.

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We expected that the group with left bundle branch pacing would do better than the group with right ventricular pacing. However, the difference between the two groups was greater than we expected. This study shows that left bundle branch pacing should be the first choice for patients with heart block who need a pacemaker.

Jörg Hausleiter

2mo

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Among these high-risk patients, transcatheter tricuspid valve repair on top of medical therapy resulted not only in quality-of-life improvements but also in meaningful and sustained reductions in hard clinical outcomes, which has not been demonstrated before with the intervention.

Dr. Viktor Kočka

Interventional Cardiologist · Charles University and University Hospital Kralovske Vinohrady

2mo

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Using the blueprint already employed for heart attacks, we were able to demonstrate that specialised interventional treatment can be delivered in tertiary care centres across our national network. This may pave the way for an improved, standardised approach to the treatment of pulmonary embolism, reducing the acute risks that patients face.

Dr. Sophia Zoungas

Lead Researcher · Monash University School of Public Health and Preventive Medicine

2mo

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A notable finding is that the lower incidence of major, nonfatal cardiovascular events with atorvastatin than with placebo did not result in a corresponding improvement in disability-frees survival. Explanations for this result might include the fact that 80% of the deaths in the trial were from non-cardiovascular causes.

Boyoung Joung

2mo

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The key impact on clinical practice is that the level of evidence about this population was actually very low, and this is the first [randomized controlled trial] to support that DOAC therapy can give benefit to this patient population.

Dr. Henning Bundgaard

Cardiologist · Copenhagen University Hospital

2mo

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It seems that from POET I and POET II we have challenged dogmas showing that less intensive antibiotic therapy after stabilization is superior and safe. And we think that defining the stabilization point is a kind of personalizing endocarditis treatment.

Nick Mills

BHF Professor of Cardiology, University of Edinburgh · University of Edinburgh

7w

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Our findings provide strong evidence that patients who have had a heart attack excluded do not benefit from early outpatient CTCA scans. Once we are confident that they haven't had a heart attack, we can reassure these patients that their future risk is low and send them home.

Carolina Malta Hansen

Physician-researcher, Copenhagen EMS, Denmark · Copenhagen EMS

16h

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Changing how an entire community responds to cardiac arrest takes time, and our findings show just how challenging that can be. In the meantime, the message to the public remains simple: learn CPR, recognize the signs of cardiac arrest, call 9-1-1 immediately and follow the dispatcher's instructions. Everyone has the potential to save a life.