Modulating circadian rhythms of immune cells may reduce the severity of myocardial infarctions that occur at night.
PRMT9 overexpression in macrophages reduced infarct size and improved cardiac function after MI by facilitating STAT1 degradation and suppressing M1-like polarization.
Spontaneous myocardial infarction occurred more frequently after PCI (6.8%) than CABG (3.4%) and was a strong predictor of cardiovascular mortality (adjHR 9.39).
In patients with diabetes and multivessel disease undergoing PCI, ticagrelor was not noninferior to prasugrel for the composite primary outcome at 1 year (16.6% vs 14.2%; P = .12).
Non-enrolled patients with acute myocardial infarction had higher long-term mortality (HR 1.15) and more reinfarctions/strokes (HR 1.16) compared to enrolled patients.
A standardized framework for evaluating predictive models and biomarkers is essential for improving cardiovascular disease prevention in diverse populations.
Atherosclerotic cardiovascular disease and cancer share risk factors and mechanisms, requiring a multidisciplinary approach to screening and management in affected patients.
A randomized clinical trial demonstrates improved sinus rhythm restoration in patients using a handheld device for Valsalva maneuver.
Driver ablation in patients with persistent atrial fibrillation resulted in 90% freedom from atrial fibrillation after 2 years of follow-up.
A meta-analysis compares 5-year outcomes of TAVI and SAVR in low- to intermediate-risk patients, indicating SAVR may be superior.