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Infections of Selected Nonvalvular Cardiovascular Devices: A ScienceAdvisory From the American Heart Association
Result: The advisory provides a contemporary profile of nonvalvular device infections and an algorithm for their evaluation in patients with bloodstream infection.
“Published today, Infections of Selected Nonvalvular Cardiovascular Devices: A Science Advisory from the American Heart Association. Nonvalvular CV device infections including intracardiac devices (e.g., septal closure devices, shunts), intravascular devices (e.g., stents, https://t.co/4KHI1JL4m4”
The Natural History of Massive Left Ventricular Hypertrophy in Pediatric Hypertrophic Cardiomyopathy: A Multiregistry Analysis
Does massive LVH increase the risk of adverse clinical outcomes in pediatric hypertrophic cardiomyopathy?
Result: Massive LVH was associated with significantly increased risk of major adverse cardiac events (HR 2.6 [95% CI 1.7–3.9]; P <0.001), major ventricular arrhythmia (HR 3.1 [1.8–5.2]; P <0.001), and heart failure (HR 1.9 [1.1–3.1]; P =0.013).
“【Title】 The Natural History of Massive Left Ventricular Hypertrophy in Pediatric Hypertrophic Cardiomyopathy: A Multiregistry Analysis 【Journal / Date / Pages】 Circulation. 2026 Apr 17. doi: 10.1161/CIRCULATIONAHA.126.078843. Online ahead of print. --- 【対象・方法】 -”
Glucagon-Like Peptide-1 Receptor Agonists in Patients with Heart Failure with Reduced Ejection Fraction
Real-world cohort study shows GLP-1RA therapy reduces mortality in heart failure patients, suggesting a potential benefit.
Workplace Wellness Programs for Employees at Risk for Cardiovascular Disease: A Systematic Review
Do employer-sponsored workplace wellness programs reduce cardiovascular disease risk factors in at-risk civilian adults?
Result: Most studies reported non-statistically significant results for CVD risk factors, but nearly half found significant improvements in systolic blood pressure.
The diagnostic value of miR-1299 in acute myocardial infarction
Key Finding: MiR-1299 expression was significantly increased in acute myocardial infarction and demonstrated high diagnostic value with an AUC of 0.895, sensitivity of 77.65%, and specificity of 88.33%.
Granulocyte colony stimulating factor for acute myocardial infarction: an updated systematic review and meta-analysis of randomized controlled trials
Systematic review reveals structural benefits of G-CSF in acute myocardial infarction, indicating need for better trials.
“Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children https://t.co/GrlXQviLoE”
A critical reflective analysis of patient and public involvement in a programme of heart failure with preserved ejection fraction research
This retrospective analysis highlights the impact of patient and public involvement on heart failure research, suggesting valuable insights for future initiatives.
Association Between Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists and Atrial Fibrillation Adverse Events: A Systematic Review and Meta-Analysis of Randomized Trials
Systematic review analyzes GLP-1 RA therapy's impact on atrial fibrillation risk in type 2 diabetes patients, suggesting potential benefits.
The use of GLP-1 RAs should not be delayed in high-risk individuals
Dementia Risk in the Decade Before and After Coronary Heart Disease Diagnosis: Hybrid Case–Control and Cohort Study
Key Finding: Dementia risk begins rising at least a decade before coronary heart disease diagnosis and peaks near the time of clinical diagnosis.
Intracoronary prourokinase for coronary embolism after aortic valve replacement: a viable treatment option?
Coronary embolism (CE) is a rare but life-threatening cause of acute myocardial infarction (AMI) in patients following mechanical aortic valve replacement (AVR), often resulting from subtherapeutic anticoagulation. Due to the absence of consensus management guidelines, treatment strategies remain individualized. A 67-year-old man with a history of mechanical AVR presented with inferior ST-segment elevation myocardial infarction after discontinuing warfarin for one week, resulting in subtherapeutic anticoagulation. Emergency coronary angiography revealed abrupt occlusion of the mid-right coronary artery (RCA) without underlying atherosclerosis. Targeted intracoronary administration of 20 mg recombinant human prourokinase (rh-proUK) via a microcatheter enabled effective thrombus aspiration and complete restoration of TIMI 3 flow without residual stenosis, thereby avoiding stent implantation. This case demonstrates that intracoronary rh-proUK administration serves as an effective rescue therapy for refractory CE when conventional interventions fail, enabling stent-free revascularization. The findings also underscore the importance of strict lifelong anticoagulation in patients with mechanical valves.