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Outcomes of Transcatheter Tricuspid Edge-to-Edge Repair and Transcatheter Valve Replacement for Severe Tricuspid Regurgitation: A Systematic Review and Meta-Analysis
How do safety and clinical outcomes compare between transcatheter tricuspid edge-to-edge repair and transcatheter tricuspid valve replacement in patients with severe tricuspid regurgitation?
Result: T-TEER was associated with very low in-hospital (0.13%) and 30-day (0.46%) mortality, whereas TTVR had higher early mortality but similar 1-year mortality, achieved more complete TR elimination, but had higher rates of permanent pacemaker implantation, thrombotic events, and major bleeding.
“Good performance of EVOQUE valve in this STS/ACC TVT Registry of Real-World Outcomes of Transcatheter Tricuspid Valve Replacement with >98% success but 16% new CIED w/o impact on 30 days outcomes. https://t.co/zipqHU6ho5”
Real-World Outcomes of Transcatheter Tricuspid Valve Replacement
Does Transcatheter Tricuspid Valve Replacement (TTVR) improve safety and effectiveness at 30 days in real-world patients with severe TR?
Result: Thirty-day outcomes demonstrated acceptable safety, near-complete TR elimination, and significant health status improvements, with lower rates of new CIED implantation and bleeding than in randomized trials.
“Good performance of EVOQUE valve in this STS/ACC TVT Registry of Real-World Outcomes of Transcatheter Tricuspid Valve Replacement with >98% success but 16% new CIED w/o impact on 30 days outcomes. https://t.co/zipqHU6ho5”
These findings show that transcatheter tricuspid valve replacement is translating well from the clinical trial setting into routine practice across the United States. In a large, older and medically complex patient population, we saw very high procedural success, near-complete elimination of tricuspid regurgitation, and rapid improvement in how patients feel and function.
Bisoprolol vs. Carvedilol After Percutaneous Coronary Intervention in Acute Myocardial Infarction With Reduced Left Ventricular Ejection Fraction
Comparative analysis shows similar cardiovascular outcomes in patients with AMI using bisoprolol or carvedilol, suggesting both are viable for prevention.
Targeted Exome Sequencing in Pre-Hospital Sudden Cardiac Arrest Reveals a High Genetic Diagnostic Yield
Does whole-exome sequencing identify clinically relevant genetic variants in young and middle-aged adults with pre-hospital sudden cardiac arrest?
Result: Pathogenic or likely pathogenic variants were identified in 13 individuals, corresponding to a diagnostic yield of 18.8%.
Study Design and Rationale of the Visualizing Subclinical Myocardial Changes with Shear Wave Elastography in Dilated Cardiomyopathy (VISUALIZE-DCM) Trial
This trial evaluates the effectiveness of shear wave elastography for detecting myocardial fibrosis in families at risk of dilated cardiomyopathy, indicating its potential for early diagnosis.
Infective endocarditis in hypertrophic cardiomyopathy: a real-world matched cohort analysis
Does hypertrophic cardiomyopathy increase the risk of infective endocarditis compared to matched controls?
Result: The 5-year cumulative incidence of IE was 3.25% in the HCM group and 1.31% in controls (HR 2.62, 95% CI 2.20 to 3.12, p<0.001).
Rate control treatment with calcium channel blockers and beta blockers for patients with atrial fibrillation: a systematic review and meta-analysis
Abstract Background and aims Controlling heart rate is a key objective in atrial fibrillation (AF) management, commonly achieved with beta blockers or non-dihydropyridine calcium channel blockers, both class I guideline recommendations. However, their long-term effectiveness has rarely been compared. This review aimed to critically evaluate all available evidence comparing these drug classes in AF treatment. Methods We systematically searched MEDLINE, Embase, Web of Science, and Cochrane Central for original studies published up to March 1st, 2025. Eligible studies included AF patients, compared calcium channel blockers and beta blockers, and reported heart rate or other clinically relevant outcomes. The primary outcome was 24-hour heart rate on Holter monitoring. Meta-analyses were performed where data were sufficiently homogeneous. Results Of 1906 identified records, 25 met inclusion criteria. Five studies reported 24-hour mean heart rate, showing no difference between drug classes (mean difference: 3.6 bpm, 95% CI: -2.9 to 10.1, P = 0.274). Eight studies reported maximum exercise heart rate, which was significantly higher with calcium channel blockers than with beta blockers (mean difference: 10.5 bpm, 95% CI: 3.3 to 17.7, P = 0.043). Other outcomes were too heterogeneous for meta-analysis, though three studies reported increased peak oxygen uptake with calcium channel blockers. Conclusion Calcium channel blockers and beta blockers provide comparable control of mean heart rate in AF. However, patients on calcium channel blockers have a higher maximum heart rate during exercise. In our qualitative synthesis, some studies reported higher peak oxygen uptake calcium channel blocker treated patients, these results should be seen as hypothesis generating.
Incidence of Infective Endocarditis Following Surgical or Transcatheter Mitral Valve Repair or Replacement: A Systematic Review and Meta-Analysis
Does bioprosthetic mitral valve replacement increase the incidence of infective endocarditis compared to mitral valve repair in patients undergoing mitral valve intervention?
Result: Infective endocarditis was significantly more common after surgical MV replacement than surgical MV repair (IRR 2.34, 95% CI 1.06-5.18, p=0.035), but not significantly different between transcatheter MV replacement and repair (IRR 1.56, 95% CI 0.73-3.34, p=0.250).
Orai1 Facilitates Angiogenesis After Myocardial Infarction Through Notch1 Signaling Pathway
Results uncover Orai1's role in angiogenesis after myocardial infarction, indicating it as a target for cardiac repair.
Yield of Postmortem Genetic Testing in Sudden Arrhythmic Death Syndrome: A Systematic Review and Meta-Analysis
Does postmortem genetic testing identify pathogenic variants in Sudden Arrhythmic Death Syndrome cases?
Result: Postmortem genetic testing identifies pathogenic or likely pathogenic variants in a significant subset of SADS cases.