“These guidelines were based on two major studies that showed a small short-term benefit to immediate treatment, but not in the long term. Our study provides more clarity: that benefit doesn't actually exist.”

“Traditionally, we've taken a stepwise approach, starting with medications and moving to procedures later. What this trial shows is that, even in patients with more advanced AFib, earlier intervention with ablation can provide substantial benefits and better control of the disease.”

“The SMART-DECISION trial is the first randomized study to demonstrate the noninferiority of beta-blocker discontinuation in post-MI patients without left ventricular systolic dysfunction or heart failure.”

“Nonobstructive HCM is a much more complex and heterogeneous population than obstructive HCM. We need to understand nonobstructive HCM better and determine whether there are subgroups that do benefit from cardiac myosin inhibitors. I suspect there may be.”