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Standardizes pre-HF identification to enable targeted prevention; extends 2021 consensus for consistent research and surveillance.

Tailored plans needed to improve GDMT access in older HF patients; extends recommendations to address age-specific barriers.

May inform perinatal HF care via expert consensus; leaves open standardized definitions and screening tools.

Supports comparable midterm valve durability for TAVR and surgery; leaves open need for extended follow-up data.

For now, the PARTNER 3 trial durability analysis offers reassuring evidence of excellent midterm outcomes in low-risk patients. As TAVR continues to move into younger populations, understanding which durability pathways matter, and in whom, will be key to building effective lifetime valve strateg...
Aficamten may be preferred over metoprolol for exercise capacity in symptomatic obstructive HCM; extends RCT evidence for myosin inhibitors versus beta-blockade.

“These findings provide compelling justification for aficamten treatment as an appropriate alternative to current first-line treatment with metoprolol, to treat exercise intolerance in oHCM.”
Standardized HF categories should now guide diagnosis, management, and trial design; extends prior EF classifications by incorporating improved function.

May favor surgery over early-generation TAVR for 10-year survival in intermediate-risk patients; challenges assumptions of long-term equivalence.

Cardiologist, NewYork-Presbyterian/Columbia University Irving Medical Center
Taken together, the studies show a likely early advantage of TAVR with respect to the important primary clinical endpoints, with a later catch-up of surgery, such that there are no major differences between the therapies at 5 years.
Scientific statement examines risk assessment for improving cardiovascular disease prevention strategies.

Observational data should not yet change practice; extends evidence on resistance training for CVD prevention in women but requires trials.

These findings suggest that, within an already active population, RT is associated with additional reductions in [cardiovascular disease] risk above and beyond overall aerobic activity. Alongside aerobic activity and reductions in sedentary behavior, RT may be an important component of public hea...
May enhance CV endpoint consistency in oncology trials; leaves open effects on outcomes or regulatory decisions pending validation.
