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Prognostic Impact of Quantitative Flow Ratio-Derived Physiology for Intermediate Non-Infarct-Related Artery in Acute Myocardial Infarction
Does QFR-derived physiology stratify high-risk non-infarct-related arteries and guide treatment in patients with acute myocardial infarction?
Result: QFR-derived physiology, including QFR and QFR-PPG, can stratify high-risk non-IRAs and guide optimal treatment in patients with AMI.
“In AMI, combining QFR with QFR-PPG unmasked high-risk non-IRA lesions. Deferred high-risk lesions had strikingly worse 3-year outcomes, whereas PCI was associated with better prognosis in this subgroup. By Sho Nakao https://t.co/PgqtOWqqUH #circ_j #CardioX https://t.co/BGol4BwiFb”
Incidence, Timing and Clinical Significance of Immune-Mediated Myocardial Injury and Myocarditis After Gene Replacement Therapy: A Systematic Review and Meta-Analysis
What is the incidence, timing, and clinical significance of immune-mediated myocardial injury and myocarditis after systemic AAV gene therapy?
Result: Immune-mediated myocarditis/myocardial injury occurred in <10 per 100 patient-years, peaking at weeks 1-3, and all events followed intravenous doses >1×10¹³ vector genomes per kilogram body weight.
“Adenovirus remains an important infectious complication following alloHCT, particularly in the setting of evolving GVHD prophylaxis strategies. This journal club will review a contemporary study evaluating the incidence, timing, and clinical outcomes of adenovirus infection in https://t.co/cFyK3KXNgd”
From Caging to Uncaging With Bioadaptors: A Novel Paradigm in Coronary Revascularization
Does the DynamX coronary bioadaptor improve clinical outcomes and restore vessel function compared to conventional drug-eluting stents in patients with coronary artery disease?
Result: The DynamX coronary bioadaptor demonstrated noninferiority to drug-eluting stents with superior late lumen preservation, reduced neointimal hyperplasia, and low target-lesion failure rates, while restoring vessel pulsatility and compliance after 6 months.
“From Caging to Uncaging With Bioadaptors: A Novel Paradigm in Coronary Revascularization | Journal of the American Heart Association https://t.co/umPCKN5822”
In-Hospital and Long-Term Clinical Outcomes in Patients With Acute Myocardial Infarction Categorized as SCAI Shock Stage B
Do in-hospital and long-term clinical outcomes differ between acute myocardial infarction patients categorized as SCAI shock stage B versus stage A?
“As compared to SCAI shock modified stage A, modified stage B was not independently associated with in-hospital and long-term clinical outcomes in patients with acute myocardial infarction. By Hisashi Sato and Kenichi Sakakura https://t.co/hM33b1dxhl #circ_rep #CardioX https://t.co/eRcVmgFz7C”
Contribution of Non-Sustained Ventricular Tachycardia to the Primary Prevention of Sudden Cardiac Death ― Validation of Current Japanese Circulation Society / Japanese Heart Rhythm Society Guideline Recommendations in the Nippon Storm Study ―
Key Takeaway: Holter-documented non-sustained ventricular tachycardia was modestly associated with an increased risk of appropriate ICD therapy (HR 1.82) but not with ventricular fibrillation or mortality.
“A history of NSVT showed limited prognostic value for primary prevention ICD therapy. Holter-documented NSVT modestly predicted appropriate ICD therapy but was not associated with VF or mortality. By Ryobun Yasuoka https://t.co/DB7T6avwKb #circ_j #CardioX https://t.co/JJIixfQYXM”
Which Is Better? Pedicled versus Skeletonized Internal Mammary Artery Grafts in Coronary Artery Bypass Grafting: Emphasis on the Antispastic Role of Perivascular Adipose
Does pedicled internal mammary artery harvesting improve vasorelaxation and clinical outcomes compared to skeletonized harvesting in patients undergoing CABG?
Result: Preservation of perivascular adipose tissue definitively preserves vasorelaxation properties of the IMA, and clinical studies suggest skeletonized harvesting is associated with a higher rate of graft occlusion and worse clinical outcomes than the pedicled technique.
Heart Failure Guideline-Directed Medical Therapy Scoring Systems: A Scoping Review
Result: Key gaps in GDMT scores include heterogeneous weighting of drug classes and doses, minimal incorporation of intolerance to identify maximum-tolerated therapy, and heterogeneous incorporation of therapies beyond quadruple therapy.
Compensating Heart Failure Cardiologists: Is the RVU Model the Right Model?
Result: The RVU model may inadequately capture the full scope of AHF care, potentially contributing to physician burnout and a decline in interest in AHF subspecialty training.
“Compensating Heart Failure Cardiologists: Is the RVU Model the Right Model? | Circulation - https://t.co/ecqCZwZFUf #GoogleAlerts”
Mycn Reactivates the Cell Cycle in Adult Cardiomyocytes and Promotes Cardioprotection in Myocardial Infarction
Result: Mycn reactivates the cardiomyocyte cell cycle and promotes cardioprotection following ischemic injury, likely via induction of a neonatal-like transcriptional program.
Risk factor profiles and haemodynamic progression in aortic stenosis: a retrospective population-based study
Key Finding: Rapid aortic stenosis progression occurred in 7.8% of patients with sclerosis, 16.4% with mild AS, and 29.8% with moderate AS, with predictors shifting from clinical to valve-related factors.