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ACC 2026 Late-Breaking Trials
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1w ago
Expert CommentaryTop JournalCirculation Highlight
Level 2: RCT
Pulsed Field Ablation Versus Sham to Treat Atrial Fibrillation: The PFA-SHAM Randomized Clinical Trial
Pulsed field ablation cuts 6-month atrial tachyarrhythmia recurrence by ~92% versus sham.
Implication
PFA markedly outperforms sham for AF recurrence and QoL; confirms ablation benefit beyond placebo in symptomatic patients.
Circulation
Charles University
5w ago
Trending on XFeatured in PodcastTop JournalNEJM Highlight
Level 2: RCT
Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation
Initial PFA cuts composite treatment failure ~54% vs. antiarrhythmic drugs in persistent AF.
Implication
Supports first-line PFA over AADs in persistent AF; challenges guidelines mandating drug trial first and extends paroxysmal AF evidence.
“These findings have implications for clinical practice, for guidelines, and for insurance coverage because “there’s a lot of people that are dissuading us from doing persistents because it’s lower yield,” Tung said.”
— TCTMDView source
New England Journal of Medicine
Johns Hopkins University
4d ago
Expert CommentaryTop JournalCirculation Highlight
Level 1: Clinical Guideline
Role of Physical Activity in Obesity Treatment and Cardiometabolic Health: A Scientific Statement From the American Heart Association
Implication
Prescribe physical activity for cardiometabolic gains irrespective of weight loss; extends evidence for multimodal obesity management.
Circulation
6w ago
Trending on XTrending on XTop JournalNEJM Highlight
Level 2: RCT
Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage
Low-dose triple antihypertensive pill cuts recurrent stroke ~39% versus placebo.
Implication
Supports single low-dose triple pill after ICH for better BP control; extends INTERACT evidence with practical adherence-enhancing approach.
“Meaningful blood pressure control after intracerebral hemorrhage requires a coordinated, systemwide commitment that integrates team-based care, expanded access to medication, and real-time monitoring to bridge the gap between clinic visits and daily management. Beyond the primary care office, eve...”
— TCTMDView source
New England Journal of Medicine
1w ago
Expert CommentaryTop JournalESC Press Release Highlight
Level 1: Clinical Guideline
Women's heart centres: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), the European Association of Percutaneous Cardiovascular Interventions (EAPCI), the Heart Failure Association (HFA), and the Association for Acute CardioVascular Care (ACVC) of the ESC
Implication
Supports women's heart centre implementation to reduce sex-based care gaps; extends consensus on specialized pathways and training.
European Heart Journal
Harvard University
3w ago
Trending on XExpert CommentaryTop JournalCirculation Highlight
Level 2: RCT
Angiotensin Receptor Neprilysin Inhibitor in Heart Failure with Preserved Ejection Fraction and Secondary Mitral Regurgitation: the PRAISE-MR Randomized Trial
Sacubitril/valsartan improves exercise mPAP/CO slope by ~0.93 mmHg/L/min versus SOC in HFpEF with AFMR.
Implication
Supports sacubitril/valsartan over SOC in HF with adverse exercise hemodynamics; extends prior ARNI trials to this invasive endpoint.
“The PRAISE-MR trial is the first prospectively randomized trial to demonstrate that sacubitril/valsartan significantly improves exercise hemodynamics, functional capacity, and quality of life in patients with HFpEF and AFMR. These findings underscore that the phenotypic heterogeneity of HFpEF nec...”
— ACC Journal ScanView source
Circulation
Vrije Universiteit Brussel
1w ago
Trending on XTop JournalACC Journal Scan Highlight
Level 1: Meta-Analysis
Adverse Effects and Treatment Discontinuation of Blood Pressure–Lowering Drugs and Combinations
CCBs increase adverse event discontinuations ~43% versus placebo while ARB monotherapy reduces them.
Implication
Adverse effects leading to discontinuation vary significantly by antihypertensive class, with ARB-containing regimens showing fewer withdrawals than placebo, suggesting better overall tolerability.
“Results from the study by Wang, et al., can help inform clinicians' selection of antihypertensive therapies for patients initiating medications for hypertension, particularly when comorbidities, such as the presence of diabetes with microvascular disease, do not warrant a specific therapy.”
— ACC Journal ScanView source
JAMA
University of Oxford
5w agoOpen Access
Top JournalCirculation Highlight
Level 2: RCT
Subcutaneous Defibrillator Implantation With or Without Defibrillation Test: The Primary Results of the Randomized PRAETORIAN-DFT Trial
PRAETORIAN score-guided omission of defibrillation testing is non-inferior to routine testing for failed first shocks.
Implication
Supports PRAETORIAN-guided omission of routine DFT in S-ICD patients; confirms non-inferior efficacy and reduced procedural risk.
“The risk-benefit ratio of routinely performing DT seems to favor not doing routine testing.”
— Raul WeissView source
Circulation
University College London
2d ago
Top Journal
Level 1: Meta-Analysis
Finerenone Across Cardiovascular-Kidney-Metabolic Syndrome Stages
Finerenone reduced cardiovascular and kidney events across CKM stages and increased CKM syndrome regression (11.4% vs 7.4%; aOR 1.66; 95% CI 1.30-2.13; P<.001) compared with placebo.
Implication
Finerenone reduces cardiovascular and kidney events and promotes CKM syndrome regression across all stages of cardiovascular-kidney-metabolic syndrome in patients with type 2 diabetes and chronic kidney disease.
“Importantly, participants who experience new-onset AFib/AFL were at a substantially higher subsequent risk of adverse cardiovascular and kidney outcomes than were those who remained free of AFib/AFL during follow-up. These findings highlight the role of finerenone in reducing the risk of new-onset AFib/AFL, mitigating downstream complications, and ultimately improving outcomes in patients across the CKM spectrum.”
— Dr. Maria A. PabonView source
JAMA Cardiology
University of Michigan
3w ago
Expert CommentaryTop JournalACC Journal Scan Highlight
Level 3: Cohort Study
Predictors of Long-Term Outcomes in Hypertrophic Cardiomyopathy
CMR LGE% predicts ~86% higher adverse event risk in HCM, alongside NT-proBNP.
Implication
LV scar burden by LGE may refine HCM risk stratification; this observational link extends prior markers but leaves open prospective validation before guiding therapy.
“This is an important next step to do a better job of identifying HCM patients at high risk," he said. "This adds to presently used risk markers derived from the patient's and their family's prior history.”
— ACC Journal ScanView source
JAMA
University of Michigan
