“Conservative oxygen therapy does not improve patients' outcomes regardless of the timing of initiation.”

“Nonobstructive HCM is a much more complex and heterogeneous population than obstructive HCM. We need to understand nonobstructive HCM better and determine whether there are subgroups that do benefit from cardiac myosin inhibitors. I suspect there may be.”

“The lack of convergence of the curves for death from cardiovascular causes and death from any causes over this prolonged period of follow-up underscores the sustained benefits of early surgery. Accordingly, we believe that early aortic valve replacement may be the preferred strategy for asymptomatic patients with severe aortic stenosis (peak aortic jet velocity ≥ 4.5 m/s).”