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Supports adoption of digitally enabled QI for LDL-C reduction in routine care; extends RCT evidence for technology-assisted lipid management.

Cardiology Researchers, epHealth UK, Scale Space, Imperial College White City Campus
In this cluster randomized clinical trial, a digitally enabled, multifaceted QI intervention embedded within routine clinical care modestly improved LDL-C control and increased use of intensive and combination [lipid-lowering therapy] among patients with established ASCVD. These findings add incremental evidence that a digitally enabled QI strategy can contribute to bridging evidence-practice gaps in secondary cardiovascular prevention and complement pharmacological advances in real-world settings, although the partial effectiveness of the present strategy indicates that further refinement of implementation strategies and digitally enabled delivery methods is needed to fully close the residual care gap.
PCI benefit in TAVI patients appears confined to severe proximal stenoses; extends NOTION-3 by refining lesion selection for revascularization.
Comparative outcomes of T-TEER versus TTVA remain limited; leaves open optimal repair strategy in secondary TR.

Screening detects high cardiometabolic burden in LMICs but weak linkage limits impact; extends evidence on implementation gaps needing integrated pathways.
TST may refine AS risk stratification in screening; leaves open whether routine use improves outcomes in asymptomatic severe AS.

Moderate MR shows similar adjusted mortality by etiology; leaves open whether phenotype-specific strategies improve outcomes.
PFA may offer a feasible option for repeat AF ablation; leaves open comparative efficacy versus RFA in randomized trials.
Avoid dual antithrombotic therapy in AF with atherosclerotic disease due to excess bleeding without efficacy gain; leaves open need for dedicated RCTs.
Supports FLX preference for LAAO in anticoagulation-intolerant AF; extends head-to-head evidence for device selection.
May support pharmacist-HF partnerships in pilots; leaves open scalability and outcome impact.
Pharm.D., Ph.D., clinical associate professor of Clinical Pharmacy and heart failure pharmacist, WVU School of Pharmacy and WVU Heart and Vascular Institute
Recent statewide data show underutilization of life-saving heart failure medications in West Virginia. To address this, we are developing a Community Pharmacy Heart Failure Certificate Program and Statewide Collaborative Network to improve health disparities in local heart failure care. This Program will help pharmacies work closely with local doctors to ensure patients get the best treatment, stay on their medications, and reduce hospital visits.