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3d agoOpen Access
Level 1: Systematic Review
Dynamic Versus Static Cardiac Biomarker Assessment for Prognostic Stratification After Percutaneous Coronary Intervention: A Systematic Review
Dynamic biomarker assessment, particularly serial measurement of NT-proBNP, provided enhanced prognostic discrimination over static baseline measurements in patients undergoing percutaneous coronary intervention.
Implication
Serial NT-proBNP monitoring may refine post-PCI risk models; leaves open prospective validation before altering practice.
Cureus
2d ago
Top JournalCirculation Highlight
Level 3: Cohort Study
Prevalence and Burden of Cardiac Amyloidosis in a Population-Based Autopsy Cohort
Implication
Population-based autopsy cohort reports the prevalence and burden of cardiac amyloidosis, indicating significant health implications.
Circulation
Mayo Clinic
3d agoOpen Access
Level 3: Cohort Study
Morbidity and Long-Term Mortality Predictors Following Isolated Mitral Valve Replacement: A Single-Center Cohort Study on the Effect of Sex
Female sex was associated with significantly higher 10-year mortality compared to male sex following isolated mitral valve replacement (36.3% vs. 30.5%; p=0.013).
Implication
May warrant heightened long-term surveillance in women after mitral valve replacement; leaves open whether sex-specific strategies improve outcomes.
Journal of Cardiovascular Development and Disease
Akdeniz University
2d ago
Top Journal
Level 1: Meta-Analysis
Safety and efficacy of mavacamten in obstructive versus non-obstructive hypertrophic cardiomyopathy: a meta-analysis of randomised controlled trials
Mavacamten improved NYHA class in obstructive HCM (OR 4.94; 95% CI 3.25-7.49), but in non-obstructive HCM it showed no functional benefit and increased the risk of LVEF declining <50%.
Implication
Supports mavacamten in obstructive HCM; cautions against non-obstructive use due to LVEF decline risk and confirms phenotype-specific effects.
Heart
University of Jordan
5d agoOpen Access
Top Journal
Level 1: Meta-Analysis
Efficacy of ARNIs on Hard Renal Outcomes in Heart Failure with and without Chronic Kidney Disease: When Endpoint Definition Matters—An Updated Meta-Analysis
Sacubitril/valsartan was associated with a lower risk of sustained 50% eGFR decline (RR 0.68; 95% CI 0.57-0.82) and composite kidney outcomes (RR 0.70; 95% CI 0.58-0.84) in heart failure.
Implication
Reinforces renal protection with sacubitril/valsartan in heart failure; extends prior meta-analyses via standardized composite kidney endpoints.
ESC Heart Failure
University of Bologna
4d ago
Top Journal
Level 2: RCT
1217-OR: ApoC3 Inhibitor Olezarsen Markedly Reduces Triglycerides and Risk of Pancreatitis in Severe Hypertriglyceridemia Patients with Diabetes Mellitus: Insights from CORE-TIMI 72a and CORE2-TIMI 72b
Olezarsen 80 mg reduced triglycerides by 64.8% (95% CI 56.0-73.6) compared with placebo in patients with severe hypertriglyceridemia and diabetes, and reduced the risk of acute pancreatitis.
Implication
Supports pancreatitis prevention with olezarsen in diabetic severe hypertriglyceridemia; extends RCT evidence from TG lowering to clinical events.
Diabetes
5d agoOpen Access
Level 1: Meta-Analysis
Conduction system pacing compared with biventricular pacing for cardiac resynchronization therapy: a systematic review and meta-analysis
Conduction system pacing significantly reduced the risk of heart failure hospitalization (RR 0.65) and improved LVEF compared with biventricular pacing in patients requiring cardiac resynchronization therapy.
Implication
CSP may be preferred over BVP for better response and fewer HF hospitalizations; extends mixed evidence but leaves open need for confirmatory RCTs.
Frontiers in Cardiovascular Medicine
Baoji City Central Hospital
2d agoOpen Access
Level 3: Cohort Study
Sex-specific non-linear association between post-procedural high-sensitivity troponin t and 12-month mortality after PCI: insights from a prospective large-scale registry
Elevated post-procedural high-sensitivity troponin T was associated with increased 12-month mortality, with a significantly stronger association in females (aHR 2.83) than in males (aHR 1.63).
Implication
May warrant sex-specific hs-TnT thresholds post-PCI; leaves open whether they improve risk stratification in ACS.
BMC Cardiovascular Disorders
3d ago
Top Journal
Level 3: Cohort Study
1261-OR: Molecular Risk Scores Enhance Type 2 Diabetes (T2D) Prediction beyond Hemoglobin A1c (HbA1c) and Body Mass Index (BMI) across Diverse Clinical Contexts
Each standard deviation increase in metabolomic risk score was associated with an increased risk of incident Type 2 Diabetes (fully adjusted HR 1.7; 95% CI 1.4-2.0).
Implication
May refine T2D risk stratification in biobanks; leaves open whether scores alter prevention or outcomes in practice.
Diabetes
2d ago
Level 3: Cohort Study
Utility of slow conduction velocity area guided ablation in patients with persistent atrial fibrillation
SCVA-guided ablation significantly improved 2-year recurrence-free survival compared to standard anatomical PVI in patients with persistent atrial fibrillation (72.6% vs 56.1%; HR 0.31; 95% CI 0.21-0.67; P=0.003).
Implication
May support SCVA-guided ablation in persistent AF; hypothesis-generating and requires randomized confirmation.
Journal of Interventional Cardiac Electrophysiology
