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Bisoprolol vs. Carvedilol After Percutaneous Coronary Intervention in Acute Myocardial Infarction With Reduced Left Ventricular Ejection Fraction
Comparative analysis shows similar cardiovascular outcomes in patients with AMI using bisoprolol or carvedilol, suggesting both are viable for prevention.
“In AMI patients with reduced LVEF undergoing PCI, bisoprolol and carvedilol showed comparable 3-year cardiovascular outcomes. Both are suitable options for secondary prevention. By Jun-Chang Jeong https://t.co/RfYpwnawv9 #circ_j #CardioX https://t.co/WrQyGDbODQ”
Targeted Exome Sequencing in Pre-Hospital Sudden Cardiac Arrest Reveals a High Genetic Diagnostic Yield
Does whole-exome sequencing identify clinically relevant genetic variants in young and middle-aged adults with pre-hospital sudden cardiac arrest?
Result: Pathogenic or likely pathogenic variants were identified in 13 individuals, corresponding to a diagnostic yield of 18.8%.
Infective endocarditis in hypertrophic cardiomyopathy: a real-world matched cohort analysis
Does hypertrophic cardiomyopathy increase the risk of infective endocarditis compared to matched controls?
Result: The 5-year cumulative incidence of IE was 3.25% in the HCM group and 1.31% in controls (HR 2.62, 95% CI 2.20 to 3.12, p<0.001).
Orai1 Facilitates Angiogenesis After Myocardial Infarction Through Notch1 Signaling Pathway
This research highlights Orai1's role in promoting angiogenesis after myocardial infarction, suggesting it as a therapeutic target.
Study Design and Rationale of the Visualizing Subclinical Myocardial Changes with Shear Wave Elastography in Dilated Cardiomyopathy (VISUALIZE-DCM) Trial
Prospective trial evaluates shear wave elastography for detecting myocardial fibrosis in dilated cardiomyopathy, suggesting new risk stratification tools.
Infections of Selected Nonvalvular Cardiovascular Devices: A ScienceAdvisory From the American Heart Association
Result: The advisory provides a contemporary profile of nonvalvular device infections and an algorithm for their evaluation in patients with bloodstream infection.
“Published today, Infections of Selected Nonvalvular Cardiovascular Devices: A Science Advisory from the American Heart Association. Nonvalvular CV device infections including intracardiac devices (e.g., septal closure devices, shunts), intravascular devices (e.g., stents, https://t.co/4KHI1JL4m4”
Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease
Key Finding: Adjunctive prednisolone added to standard primary treatment for Kawasaki disease did not reduce the incidence of coronary-artery lesions at 1 month after illness onset.
“なんとNEJM Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease | New England Journal of Medicine https://t.co/lXJVbmWINA”
Glucocorticoids in Kawasaki Disease — Refining Indications and the Science
Workplace Wellness Programs for Employees at Risk for Cardiovascular Disease: A Systematic Review
Do employer-sponsored workplace wellness programs reduce cardiovascular disease risk factors in at-risk civilian adults?
Result: Most studies reported non-statistically significant results for CVD risk factors, but nearly half found significant improvements in systolic blood pressure.
WNT5a-Mediated Aberrant Actin Filament Dynamics Drive Cardiac Pathogenic Phenotypes in LMNA -Related Emery-Dreifuss Muscular Dystrophy
We present WNT5a-mediated aberrant actin filament dynamics as a novel mechanism underlying cardiac pathogenic phenotypes in LMNA-related EDMD. Our findings indicate that activating WNT5a/RhoA and stabilizing actin assembly may serve as novel therapeutic strategies for this condition.