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Investigación destacada hoy
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2w ago
Comentario expertoRevista destacadaDestacado en Circulation
Level 2: RCT
Pulsed Field Ablation Versus Sham to Treat Atrial Fibrillation: The PFA-SHAM Randomized Clinical Trial
Pulsed field ablation cuts 6-month atrial tachyarrhythmia recurrence by ~92% versus sham.
Implicación
PFA markedly outperforms sham for AF recurrence and QoL; confirms ablation benefit beyond placebo in symptomatic patients.
Circulation
Charles University
1w ago
Comentario expertoRevista destacadaDestacado en Circulation
Level 1: Clinical Guideline
Role of Physical Activity in Obesity Treatment and Cardiometabolic Health: A Scientific Statement From the American Heart Association
Implicación
Prescribe physical activity for cardiometabolic gains irrespective of weight loss; extends evidence for multimodal obesity management.
Circulation
6w ago
Destacado en podcastComentario expertoRevista destacadaDestacado en ACC Journal Scan
Level 2: RCT
Risk-Based Nurse-Managed Personalized Heart Failure Interventions
Implicación
Randomized trial assesses safety and efficacy of personalized heart failure interventions in patients, indicating limited improvement in outcomes.
“A key lesson from the ALLEVIATE-HF trial is that alerts are not treatment, and signals without a timely response lose their clinical impact. Future studies should stop treating the alert as the intervention and instead define the alert-to-action pathway as the true intervention.”
— ACC Journal ScanVer fuente
Journal of the American College of Cardiology
The Ohio State University
5d ago
Comentario expertoDestacado en podcastRevista destacadaDestacado en Circulation
Level 1: Clinical Guideline
Use of Predicted Risk and Expected Benefit to Guide Decision-Making in Cardiovascular-Kidney-Metabolic Syndrome for the Primary Prevention of Cardiovascular Disease: A Scientific Statement From the American Heart Association and American College of Cardiology
Implicación
Scientific statement examines risk assessment for improving cardiovascular disease prevention strategies.
Circulation
5w ago
Tendencia en XComentario expertoRevista destacadaDestacado en Circulation
Level 2: RCT
Angiotensin Receptor Neprilysin Inhibitor in Heart Failure with Preserved Ejection Fraction and Secondary Mitral Regurgitation: the PRAISE-MR Randomized Trial
Sacubitril/valsartan improves exercise mPAP/CO slope by ~0.93 mmHg/L/min versus SOC in HFpEF with AFMR.
Implicación
Supports sacubitril/valsartan over SOC in HF with adverse exercise hemodynamics; extends prior ARNI trials to this invasive endpoint.
“The PRAISE-MR trial is the first prospectively randomized trial to demonstrate that sacubitril/valsartan significantly improves exercise hemodynamics, functional capacity, and quality of life in patients with HFpEF and AFMR. These findings underscore that the phenotypic heterogeneity of HFpEF nec...”
— ACC Journal ScanVer fuente
Circulation
Vrije Universiteit Brussel
2w ago
Comentario expertoRevista destacadaDestacado en ESC Press Release
Level 1: Clinical Guideline
Women's heart centres: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), the European Association of Percutaneous Cardiovascular Interventions (EAPCI), the Heart Failure Association (HFA), and the Association for Acute CardioVascular Care (ACVC) of the ESC
Implicación
Supports women's heart centre implementation to reduce sex-based care gaps; extends consensus on specialized pathways and training.
European Heart Journal
Harvard University
1w agoOpen Access
Comentario expertoRevista destacadaDestacado en Circulation
Level 3: Cohort Study
Lifestyle-Induced Visceral Fat Loss as a Key Target for Durable Cardiometabolic Health: MRI-Assessed 5- and 10-Year Follow-Up After 2 Clinical Trials
Each 10% intervention-induced loss of visceral adipose tissue was associated with a 28% lower risk of incident type 2 diabetes (HR 0.72; 95% CI 0.54-0.94) during 5- and 10-year follow-up.
Implicación
Visceral fat loss may inform diabetes prevention targets; hypothesis-generating and requires randomized confirmation.
“Repeated participation in a lifestyle program for weight loss, even after a perceived 'failure,' may lead to significant health benefits over the years, especially in reducing dangerous abdominal fat.”
— Iris ShaiVer fuente
Circulation
Harvard University
2w ago
Tendencia en XRevista destacadaDestacado en ACC Journal Scan
Level 1: Meta-Analysis
Adverse Effects and Treatment Discontinuation of Blood Pressure–Lowering Drugs and Combinations
CCBs increase adverse event discontinuations ~43% versus placebo while ARB monotherapy reduces them.
Implicación
CCBs raise and ARBs lower adverse-event discontinuations versus placebo; extends class-specific tolerability data to inform initial antihypertensive selection.
“Results from the study by Wang, et al., can help inform clinicians' selection of antihypertensive therapies for patients initiating medications for hypertension, particularly when comorbidities, such as the presence of diabetes with microvascular disease, do not warrant a specific therapy.”
— ACC Journal ScanVer fuente
JAMA
University of Oxford
1w ago
Revista destacada
Level 1: Meta-Analysis
Finerenone Across Cardiovascular-Kidney-Metabolic Syndrome Stages
Finerenone reduced cardiovascular and kidney events across CKM stages and increased CKM syndrome regression (11.4% vs 7.4%; aOR 1.66; 95% CI 1.30-2.13; P<.001) compared with placebo.
Implicación
Supports finerenone across CKM stages in T2D-CKD; extends prior RCTs to include syndrome regression.
“Importantly, participants who experience new-onset AFib/AFL were at a substantially higher subsequent risk of adverse cardiovascular and kidney outcomes than were those who remained free of AFib/AFL during follow-up. These findings highlight the role of finerenone in reducing the risk of new-onset AFib/AFL, mitigating downstream complications, and ultimately improving outcomes in patients across the CKM spectrum.”
— Dr. Maria A. PabonVer fuente
JAMA Cardiology
University of Michigan
1w ago
Revista destacada
Level 2: RCT
Precardioversion Heart Rhythm Monitoring Using Smartphone Photoplethysmography
Precardioversion monitoring using smartphone photoplethysmography significantly reduced same-day cancellations of scheduled cardioversions compared to standard care (4.8% vs 23.2%; P<.001).
Implicación
Reduces same-day cancellations and resource waste in AF cardioversion; extends smartphone photoplethysmography evidence to preprocedural monitoring.
JAMA Cardiology
Karolinska Institutet
