Does discontinuation of OAC after successful catheter ablation for atrial fibrillation safely prevent thromboembolic events compared to continued therapy?

Result: The incidence of thromboembolic events in patients who discontinued OAC after successful ablation remained low, though evaluation of net clinical benefit was limited by a low number of events.

Does surgical mitral valve replacement in rheumatic heart disease patients yield similar one-year mortality compared to non-rheumatic heart disease patients and across different center volumes?

Result: One-year mortality did not differ significantly between RHD (6.4%) and non-RHD (13.8%) MVR patients (HR: 0.80; 95% CI 0.53-1.21; p=0.288).

Result: Summarizes 2025 advances in cardiovascular pharmacotherapy, including 4 new drug approvals (aficamten, etripamil, lerodalcibep, plozasiran), label expansions, major RCT results, and the withdrawal of Andexanet-alfa.

Does once-weekly tirzepatide reduce cardiovascular events compared to dulaglutide in patients aged ≥40 years with type 2 diabetes mellitus and established ASCVD?

Result: The primary composite endpoint occurred in 12.2% of patients treated with tirzepatide and 13.1% of those treated with dulaglutide (HR 0.92, 95.3% CI: 0.83–1.01), meeting non-inferiority (P = 0.003) but not superiority (P = 0.09).

What are the mechanisms and consequences of vertical transmission of Group B Coxsackieviruses from mother to infant?

Result: Vertical transmission of CV-B can occur through transplacental passage or inhalation during delivery, leading to serious consequences including abortion, stillbirth, congenital malformations, and neonatal morbidity and mortality.

Result: Round 1 showed 50% of items with I-CVIs <0.78 (S-CVI/AVE=0.77), prompting revisions, and final I-CVIs exceeded 0.78 for >95% of items.

Does whole-body vibration training reduce resting blood pressure in adults?

Result: WBVT significantly reduced resting BP in adults, particularly effective in those with higher baseline BP, overweight/obese, or using combined exercise protocols.

Does the sequential delivery of M2a, M2b, and M2c immune cell-mimicking nanoparticles improve tissue repair and recovery in myocardial infarction?

Result: Sequential delivery of M2a, M2b, and M2c nanoparticles emerged as the most effective approach for promoting MI recovery among various delivery strategies tested.

Does higher depressive burden increase the odds of prevalent myocardial infarction in US adults?

Result: In the unadjusted model, every 1-point increase in PHQ-9 score corresponded to a 6.2% increase in the odds of MI (OR = 1.062, 95% CI: 1.047–1.077; p < 0.001), while severe depression was linked to approximately a 2.56-fold higher odds compared with non-depressed participants.

Does exercise-based prehabilitation improve postoperative outcomes in adults aged ≥ 65 years undergoing major abdominal, cardiac, or vascular surgery?

Result: Vascular surgery studies showed modest reductions in complications and hospital stay, whereas abdominal surgery studies generally reported no significant improvements; no studies involving cardiac surgery were identified.