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4d ago
Top JournalCirculation Highlight
Level 2: RCT
Heart Rate and Cardiovascular Outcomes in Post–Myocardial Infarction Patients Treated by β-Blockers: A Secondary Analysis of the ABYSS Trial
Higher baseline heart rate (≥68 vs <60 bpm) increased the risk of death, MI, or stroke (9.2% vs 5.5%; HR 1.55, 95% CI 1.14-2.12), and β-blocker interruption consistently worsened outcomes.
Implication
Supports avoiding β-blocker interruption in patients with higher baseline heart rate; confirms resting heart rate as an independent prognostic marker in secondary prevention.
“Knowing our results now, I would probably not stop a drug that is well tolerated [and whose] cost is quite low. In people on chronic beta-blocker therapy, you've already selected [out] people who don't tolerate the drug, so there's not much benefit of stopping [in those on long-term treatment]. What we show here is that there's a safety signal to stopping.”
— Johanne SilvainView source
Circulation
Sorbonne Université
4d ago
Trending on XTop Journal
Level 3: Cohort Study
Cost Offset With Quadruple Therapy for Heart Failure
Full quadruple GDMT implementation was projected to reduce hospitalization-associated expenditures by $9780 (95% CI, 7900-11660) per patient annually compared to partial GDMT.
Implication
Supports quadruple GDMT implementation to cut HF hospitalizations and costs; extends RCT evidence via large-scale modeling.
JAMA Cardiology
University of California, Los Angeles
4d agoOpen Access
Trending on X
Level 1: Systematic Review
Cardiac Arrest in Athletes, Footballers, and the General Population: A Contemporary Analysis of Risk Factors, Prevention, and Emergency Response Strategies
Bystander CPR and public AED use were associated with a 2- to 4-fold increase in survival (OR 2.5-4.2) following sudden cardiac arrest.
Implication
Bystander CPR and AED access should expand in athletic venues; extends evidence for athlete-specific risk stratification and screening.
Gulu University
St. Francis Hospital
3d ago
Trending on XTop Journal
Level 3: Cohort Study
Sex-specific associations between midlife body mass index and later-life left atrial enlargement in the Hordaland health study
Overweight was associated with a significantly higher risk of LAE in women than men (RR 1.45, 95% CI 1.27 to 1.65 vs RR 1.26, 95% CI 1.09 to 1.46; risk difference 0.16, 95% CI 0.08 to 0.25).
Implication
May signal higher risk; hypothesis-generating and should not yet change practice or risk models.
Heart
University of Bergen
3d agoOpen Access
Trending on X
Level 3: Cohort Study
Longitudinal Changes in Hematological Status and Functional Capacity During Hospitalization Are Associated With Clinical Outcomes in Older Patients With Acute Decompensated Heart Failure
An increase in the hemoglobin-to-red cell distribution width ratio during hospitalization for acute decompensated heart failure was associated with a lower risk of all-cause death (adjusted HR 0.72).
Implication
High mortality persists despite hospitalization; leaves open whether ∆Hb/RDW with 6MWD changes aids prognostication.
Circulation Reports
Kōchi University
3d agoOpen Access
Trending on X
Level 3: Cohort Study
Prognostic Impact of Gait Speed Changes During Hospitalization in Patients Undergoing Transcatheter Aortic Valve Implantation
A decline in gait speed during hospitalization for transcatheter aortic valve implantation was associated with a higher risk of post-discharge all-cause mortality, even among patients with normal baseline gait speed (HR 1.905).
Implication
Normal/DG patients show higher post-discharge mortality; this observational link leaves open whether DG modifies risk and requires prospective confirmation.
Circulation Reports
Nagasaki University
4d agoOpen Access
Trending on X
Level 3: Cohort Study
Association Between Registered Instructors of Cardiac Rehabilitation and Inpatient Cardiac Rehabilitation Participation in Japan ― A Nationwide 10-Year Analysis ―
A higher density of Registered Instructors of Cardiac Rehabilitation was positively associated with higher prefecture-level inpatient cardiac rehabilitation participation rates in 2023 (r=0.31).
Implication
May support scaling RICRs to boost CR participation; leaves open causality in this observational analysis.
Circulation Reports
National Cerebral and Cardiovascular Center
4d agoOpen Access
Trending on X
Level 3: Cohort Study
Association of achieved LDL-C levels with global coagulability and clinical outcomes in patients with acute coronary syndrome receiving PCSK9 inhibitors: a prospective cohort study
Achieving an LDL-C level ≤ 0.78 mmol/L in ACS patients on PCSK9 inhibitors and DAPT did not significantly increase the risk of clinically relevant bleeding compared to higher LDL-C levels (6.7% vs 5.0%, p=0.72).
Implication
No increased bleeding risk observed with ultra-low LDL-C on PCSK9 inhibitors plus DAPT; hypothesis-generating for safety in ACS and requires RCT validation.
Frontiers in Cardiovascular Medicine
First People’s Hospital of Zunyi
3d agoOpen Access
Trending on X
Level 1: Systematic Review
Explainable Artificial Intelligence in Valvular Heart Disease: A Systematic Review
Explainable Artificial Intelligence in valvular heart disease predominantly utilized Shapley Additive Explanations (66% of 52 studies), though rigorous clinical validation remains rare.
Implication
XAI in valvular heart disease lacks rigorous clinician-validated evaluation; leaves open standardized transparency metrics before clinical use.
Indian Journal of Clinical Cardiology
Government Medical College
3d agoOpen Access
Trending on X
Level 1: Systematic Review
Artificial intelligence in the clinical management and prognostication of mitral regurgitation: a systematic review
Artificial intelligence models, particularly those trained on echocardiographic imaging, demonstrated strong discriminatory performance for mitral regurgitation evaluation with reported AUCs ranging from 0.74 to 0.94.
Implication
AI may refine MR assessment precision in practice; extends AI evidence in valvular disease but leaves open need for prospective trials.
The Egyptian Heart Journal
University of Naples Federico II
