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RCT · n=7847 ErwähnungenTrending on XTrending on X
30. JULIOosterom-EijmaelJAMA
Dapagliflozin before elective cardiac surgery reduces 7-day AKI ~46% versus placebo.
Perioperative dapagliflozin reduces postoperative AKI; extends SGLT2i use to cardiac surgery prevention.
DWDr. Wolfgang C. Winkelmayer
nephrologist, Baylor College of Medicine
Hereon, investigators should aim to better understand the mechanism(s) by which SGLT2 inhibitors reduce the risk of AKI among patients undergoing elective cardiac surgery as well as those with type 2 diabetes, heart failure, and chronic kidney disease treated with SGLT2 inhibitors longer-term. Moreover, they should briskly and rigorously conduct randomized, placebo-controlled clinical trials of SGLT2 inhibitors in established AKI, aiming to arrest or attenuate its evolution and/or hasten its recovery.
meta-analysis · n=73,7371 ErwähnungenExpert CommentaryTrending on X
4. AUG.SiegalCirculation
OACs in AF are linked to a ~26% incidence of clinically relevant extracranial bleeding.
Clinicians should integrate extracranial bleeding risk into OAC decisions for AF; this meta-analysis extends trial data by quantifying baseline factors' contribution to most attributable risk.
systematic_review · n=52,0002 Erwähnungen
31. JULIFanousEuropean Heart Journal - Quality of Care and Clinical Outcomes
Digital and workflow interventions boost 1-year AVR rates by ~30% and shorten TAVI wait times.
Persistent severe AS pathway delays warrant targeted workflow reforms now; extends evidence base for digital and organizational interventions.
RCT · n=2796 Erwähnungen
30. JULIPüntmannNature Communications
Losartan plus prednisolone fails to improve LVEF over placebo in post-COVID syndrome.
First RCT of anti-inflammatory therapy in post-COVID cardiac involvement; leaves open whether losartan plus prednisolone improves symptoms or imaging.
ARAnonymous Reviewer
Peer Reviewer, Springer Nature
The manuscript is well written, the introduction and aim are easy to follow, and the results are somewhat easy to follow. Notwithstanding, this reviewer is somewhat uneasy about the presentation of the changes in anatomical and functional measurements.
meta-analysis · n=39,4522 ErwähnungenTrending on X
3. AUG.PackHeart
Pharmacological BP lowering cuts CV death and HF hospitalization ~14%, regardless of reduction degree.
BP lowering shows no outcome benefit in HFmrEF/HFpEF; leaves open whether it mediates therapy effects or warrants targeted trials.
cohort · n=1,1609 ErwähnungenTrending on X
3. AUG.AyestaránCirculation
LV hypertrabeculation in dilated cardiomyopathy is not associated with increased embolic risk.
Hypertrabeculation in DCM was not linked to higher embolic risk; leaves open its prognostic value across genotypes in prospective studies.
DNDr. Nerea Mora
Cardiologist, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
The presence of hypertrabeculation did not modify clinical risk in any of the genetic subgroups analyzed, confirming that it does not confer a worse prognosis.
cohort · n=271,4964 ErwähnungenTrending on X
31. JULIDeringtonUniversity of Pennsylvania
One-year BP control among Veterans remains largely unchanged despite 2017 target-lowering guidelines and the pandemic.
Low BP control persisted after 2017 guideline and during COVID; leaves open how to overcome therapeutic inertia in incident hypertension.
meta-analysis · n=2,2232 Erwähnungen
3. AUG.Al-shammariCardio-Oncology
Spironolactone improves LVEF by ~13% vs placebo during cardiotoxic chemotherapy for breast cancer.
May guide cardioprotective drug selection during breast cancer chemotherapy; extends comparative RCT evidence on LVEF preservation.
cohort · n=1573 ErwähnungenTrending on X
1. AUG.MatsumotoJournal of Cardiovascular Electrophysiology
LLM-based framework matches CNN performance for localizing PVC origins from 12-lead ECGs.
May support interpretable ECG analysis for PVC localization; leaves open prospective validation before clinical use.
cohort · n=2,4431 Erwähnungen
31. JULIAnJournal of the American Heart Association
Young men with high blood pressure are diagnosed ~36% less often and later than women.
Diagnostic delays may occur in young adults with high BP, especially men; leaves open whether targeted screening improves timely diagnosis.
