Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling

Key Points

• The study demonstrates the effectiveness of dna-encoded libraries in identifying protein ligands through compound screening.
• By employing sequential amide coupling, a lead-like dna-encoded library was successfully synthesized, enhancing compound diversity.
• The method maximizes the efficiency of ligand identification while offering a cost-effective screening alternative.
• The findings emphasize potential applications of dna-encoded libraries in drug discovery and compound libraries.