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September 10, 2025RSC Medicinal ChemistryOpen Access

Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling

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The study demonstrates the effectiveness of dna-encoded libraries in identifying protein ligands through compound screening.
By employing sequential amide coupling, a lead-like dna-encoded library was successfully synthesized, enhancing compound diversity.
The method maximizes the efficiency of ligand identification while offering a cost-effective screening alternative.
The findings emphasize potential applications of dna-encoded libraries in drug discovery and compound libraries.

Implication

Synthesis of diverse compounds using dna-encoded libraries improves ligand screening efficiency.

Abstract

DNA-encoded libraries (DELs) are established as an effective screening strategy to identify protein ligands and offer a cost-effective means of screening large numbers of compounds. However, the synthesis and utilisation...

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Cite This Study

Taylor et al. (2025) studied this question.

synapsesocial.com/papers/68c1ae6654b1d3bfb60e60f2 https://doi.org/10.1039/d5md00350d

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Implication

Synthesis of diverse compounds using dna-encoded libraries improves ligand screening efficiency.

Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling

Key Points

Implication

Abstract

Discussion

Cite This Study

Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling

Key Points

Implication

Abstract

Discussion

Cite This Study

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