Figure S12 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

• Radiotherapy reduces metastases in Ewing sarcoma, enhancing immune infiltration significantly.
• Key evidence shows that TGFβ inhibition resulted in a marked increase in immune cell presence in tumor samples.
• Transcriptional modulation was assessed using Ewing sarcoma tumors in a mouse model, comparing hu-CD34+ mice and NSG mice.
• These findings suggest that targeting TGFβ during treatment may improve patient outcomes in metastatic Ewing sarcoma.