Figure S12 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley; Elina Mukherjee; David Ferraro; A. Carolina Tufino; Nathanael G. Bailey; Shanthi Bhaskar; Nivitha Periyapatna; Ian MacFawn; Sean Hartwick; Sheryl Kunning; Cynthia S. Hinck; Tullia C. Bruno; Adam C. Olson; Linda M. McAllister‐Lucas; Andrew P. Hinck; Kristine Cooper; Riyue Bao; Anthony R. Cillo; Kelly M. Bailey

doi:10.1158/2767-9764.29992596

Key Points

Radiotherapy reduces metastases in Ewing sarcoma, enhancing immune infiltration significantly.
Key evidence shows that TGFβ inhibition resulted in a marked increase in immune cell presence in tumor samples.
Transcriptional modulation was assessed using Ewing sarcoma tumors in a mouse model, comparing hu-CD34+ mice and NSG mice.
These findings suggest that targeting TGFβ during treatment may improve patient outcomes in metastatic Ewing sarcoma.

Implication

Experimental findings demonstrate increased immune cell infiltration and decreased metastases in Ewing sarcoma post-radiotherapy, suggesting TGFβ plays a critical role.

Abstract

Figure S12. Transcriptional modulation induced following radiation in A673 Ewing sarcoma tumors developed in hu-CD34+ versus NSG mice.

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f8564 https://doi.org/10.1158/2767-9764.29992596

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Figure S12 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S12 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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