Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley; Elina Mukherjee; David Ferraro; A. Carolina Tufino; Nathanael G. Bailey; Shanthi Bhaskar; Nivitha Periyapatna; Ian MacFawn; Sean Hartwick; Sheryl Kunning; Cynthia S. Hinck; Tullia C. Bruno; Adam C. Olson; Linda M. McAllister‐Lucas; Andrew P. Hinck; Kristine Cooper; Riyue Bao; Anthony R. Cillo; Kelly M. Bailey

doi:10.1158/2767-9764.29992602

Key Points

TGFβ inhibition enhances immune cell infiltration in Ewing sarcoma tumors, leading to better treatment outcomes.
Assessment of tumor growth reveals similar patterns in humanized and NSG mouse models during treatment.
Ewing sarcoma intervention showed reduced metastases in response to TGFβ inhibition during radiotherapy.
The findings suggest that targeting TGFβ could be a promising strategy in Ewing sarcoma therapies.

Implication

Observational analysis shows increased immune cell infiltration and reduced metastases in Ewing sarcoma, indicating potential therapeutic benefits of TGFβ inhibition.

Abstract

Figure S10. Ewing sarcoma tumor growth is similar in humanized and NSG mouse models.

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f876e https://doi.org/10.1158/2767-9764.29992602

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Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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