Figure S13 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Inhibition of TGFβ enhances immune cell infiltration and reduces metastases in Ewing sarcoma tumors.
Radiation therapy activates inflammatory pathways, significantly impacting tumor behavior in treated models.
Using a hu-CD34+ mouse model, the findings illustrate a potential strategy to improve Ewing sarcoma treatment.
The results highlight the need for further investigation into combining TGFβ inhibitors with radiotherapy.

Analysis shows that TGFβ inhibition increases immune cell infiltration in Ewing sarcoma, suggesting improved responses during radiotherapy.

Figure S13. Radiation therapy induces upregulation of inflammatory pathways in Ewing sarcoma tumors developed in a hu-CD34+ mouse model.

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Daley et al. (2025) studied this question.

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