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August 27, 2025Open Access

Figure S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley Elina Mukherjee David Ferraro A. Carolina Tufino Nathanael G. Bailey Shanthi Bhaskar Nivitha Periyapatna Ian MacFawn Sean Hartwick Sheryl Kunning Cynthia S. Hinck Tullia C. Bruno Adam C. Olson Linda M. McAllister‐Lucas Andrew P. Hinck Kristine Cooper Riyue Bao Anthony R. Cillo Kelly M. Bailey

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Key Points

TGFβ inhibition during radiotherapy decreases metastases in Ewing sarcoma, enhancing treatment effectiveness.
The study shows increased immune cell infiltration correlated with decreased tumor spread in Ewing sarcoma cases.
Analysis of immune cell expression was conducted in human Ewing tumors, measuring TGFβ levels and effects.
These results highlight the potential for integrating TGFβ inhibition in cancer therapies for better outcomes.

Implication

Radiotherapy reduces metastases and enhances immune cell infiltration in Ewing sarcoma, suggesting TGFβ's role in treatment.

Abstract

Figure S1. TGFβ1 expression is present in the immune cell compartment of human Ewing tumors.

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f84f3 https://doi.org/10.1158/2767-9764.29992605

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
2Figure S9 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
3Figure S13 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
4Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
5Figure S8 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025