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August 27, 2025Open Access

Figure S8 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley Elina Mukherjee David Ferraro A. Carolina Tufino Nathanael G. Bailey Shanthi Bhaskar Nivitha Periyapatna Ian MacFawn Sean Hartwick Sheryl Kunning Cynthia S. Hinck Tullia C. Bruno Adam C. Olson Linda M. McAllister‐Lucas Andrew P. Hinck Kristine Cooper Riyue Bao Anthony R. Cillo Kelly M. Bailey

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Key Points

Metastases decreased in Ewing sarcoma tumors treated with TGFβ inhibition, improving treatment efficacy.
Immune cell infiltration increased significantly, indicating a stronger immune response to the tumors.
Ewing sarcoma tumors in hu-CD34+ mice showed upregulation of ECM pathways, reflecting changes in tumor microenvironment.
Findings suggest potential therapeutic implications of TGFβ inhibition for better outcomes in Ewing sarcoma patients.

Implication

Analysis reveals TGFβ inhibition enhances immune cell infiltration and correlates with reduced metastasis in Ewing sarcoma samples.

Abstract

Figure S8. Ewing sarcoma tumors developed in hu-CD34+ mice demonstrate upregulation of ECM pathways.

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f87d1 https://doi.org/10.1158/2767-9764.29992554

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S13 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
2Figure S9 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
3Figure S12 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
4Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
5Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025