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August 27, 2025Open Access

Figure S7 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley Elina Mukherjee David Ferraro A. Carolina Tufino Nathanael G. Bailey Shanthi Bhaskar Nivitha Periyapatna Ian MacFawn Sean Hartwick Sheryl Kunning Cynthia S. Hinck Tullia C. Bruno Adam C. Olson Linda M. McAllister‐Lucas Andrew P. Hinck Kristine Cooper Riyue Bao Anthony R. Cillo Kelly M. Bailey

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Key Points

Inhibition of TGFβ during radiotherapy decreases metastases in ewing sarcoma, improving patient outcomes.
Bulk RNA sequencing indicated enhanced immune cell infiltration in tumors treated with TGFβ inhibition.
Observational analysis of ewing sarcoma tumors in hu-CD34+ and NSG mouse models revealed significant interactions.
These findings support further research on TGFβ as a therapeutic target in ewing sarcoma treatment.

Implication

Ewing sarcoma treatment with TGFβ inhibition increases immune cell infiltration, suggesting improved outcomes.

Abstract

Figure S7. Bulk RNA sequencing was performed on TC32 Ewing sarcoma tumors developed in either hu-CD34+ or NSG mouse models.

Discussion

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f84f6 https://doi.org/10.1158/2767-9764.29992557

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
2Figure S12 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
3Figure S8 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
4Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
5Figure S13 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025