Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley; Elina Mukherjee; David Ferraro; A. Carolina Tufino; Nathanael G. Bailey; Shanthi Bhaskar; Nivitha Periyapatna; Ian MacFawn; Sean Hartwick; Sheryl Kunning; Cynthia S. Hinck; Tullia C. Bruno; Adam C. Olson; Linda M. McAllister‐Lucas; Andrew P. Hinck; Kristine Cooper; Riyue Bao; Anthony R. Cillo; Kelly M. Bailey

doi:10.1158/2767-9764.29992599

Key Points

TGFβ inhibition during radiotherapy significantly increases immune cell infiltration in tumors.
Distinct tumor transcriptional signatures are observed in Ewing sarcomas from different mouse models.
Inhibition leads to decreased metastases, indicating a potential therapeutic strategy.
Study used hu-cD34+ and NSG mouse models to evaluate responses to radiotherapy.

Implication

Analysis reveals TGFβ inhibition enhances immune cell infiltration in Ewing sarcoma, suggesting improved outcomes.

Abstract

Figure S11. Distinct tumor transcriptional signatures following radiation therapy are noted in Ewing sarcomas developed in hu-cD34+ versus NSG mouse models.

Discussion

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f876a https://doi.org/10.1158/2767-9764.29992599

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Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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