Figure S19 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley; Elina Mukherjee; David Ferraro; A. Carolina Tufino; Nathanael G. Bailey; Shanthi Bhaskar; Nivitha Periyapatna; Ian MacFawn; Sean Hartwick; Sheryl Kunning; Cynthia S. Hinck; Tullia C. Bruno; Adam C. Olson; Linda M. McAllister‐Lucas; Andrew P. Hinck; Kristine Cooper; Riyue Bao; Anthony R. Cillo; Kelly M. Bailey

doi:10.1158/2767-9764.29992575

Key Points

TGFβ signaling was significantly decreased in tumors receiving RER compared to those treated with only radiation therapy.
The combination of TGFβ inhibition and radiation therapy enhanced immune cell infiltration within the tumors.
Observed reductions in metastases were linked to the combined treatment approach, indicating potential therapeutic benefits.
This study utilizes a mouse model to investigate the effects of TGFβ inhibition in Ewing sarcoma during radiation therapy.

Implication

Analysis reveals decreased TGFβ signaling after combined RER and radiation therapy in Ewing sarcoma, suggesting improved immune responses.

Abstract

Figure S19. TGFβ signaling is decreased in tumors of mice that receive RER following radiation therapy as compared to mice that are treated with radiation therapy (RT) alone.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f8550 https://doi.org/10.1158/2767-9764.29992575

View Full Paper

Ask AI

Bookmark

Share

Figure S19 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S19 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading