Figure S16 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley; Elina Mukherjee; David Ferraro; A. Carolina Tufino; Nathanael G. Bailey; Shanthi Bhaskar; Nivitha Periyapatna; Ian MacFawn; Sean Hartwick; Sheryl Kunning; Cynthia S. Hinck; Tullia C. Bruno; Adam C. Olson; Linda M. McAllister‐Lucas; Andrew P. Hinck; Kristine Cooper; Riyue Bao; Anthony R. Cillo; Kelly M. Bailey

doi:10.1158/2767-9764.29992584

Key Points

TGFβ inhibition significantly enhances immune cell infiltration and reduces metastases in Ewing sarcoma models.
Experimental results indicate improved survival rates for mice treated with TGFβ inhibition and radiotherapy.
The approach involved assessing survival of mice treated with ± RER and ± radiation therapy.
These findings suggest TGFβ inhibition during radiotherapy may improve outcomes for Ewing sarcoma, highlighting a potential therapeutic strategy.

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Implication

Figure shows enhanced immune cell infiltration and reduced metastases in mice with Ewing sarcoma, suggesting TGFβ inhibition may improve radiotherapy efficacy.

Abstract

Figure S16. Survival of mice treated with ± RER and ± radiation therapy.

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Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f84f2 https://doi.org/10.1158/2767-9764.29992584

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Figure S16 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Figure S16 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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