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August 27, 2025Open Access

Figure S2 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley Elina Mukherjee David Ferraro A. Carolina Tufino Nathanael G. Bailey Shanthi Bhaskar Nivitha Periyapatna Ian MacFawn Sean Hartwick Sheryl Kunning Cynthia S. Hinck Tullia C. Bruno Adam C. Olson Linda M. McAllister‐Lucas Andrew P. Hinck Kristine Cooper Riyue Bao Anthony R. Cillo Kelly M. Bailey

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Key Points

Inhibiting TGFβ decreases metastases in Ewing sarcoma, leading to a more effective immune response.
TGFβ1 was identified as the main isoform expressed by immune cells in human Ewing tumors.
Research shows that enhancing immune cell infiltration via TGFβ inhibition can improve treatment outcomes.
Findings imply a need for further exploration of TGFβ-targeted therapies in Ewing sarcoma management.

Implication

Inhibition of TGFβ shows improved immune cell infiltration and reduced metastasis in Ewing sarcoma, indicating a potential therapeutic strategy.

Abstract

Figure S2. TGFβ1 is the predominant TGFβ isoform expressed by immune cells in human Ewing tumors.

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f84f1 https://doi.org/10.1158/2767-9764.29992572

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
2Figure S9 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
3Figure S13 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
4Figure S8 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
5Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025