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August 27, 2025Open Access

Table S4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley Elina Mukherjee David Ferraro A. Carolina Tufino Nathanael G. Bailey Shanthi Bhaskar Nivitha Periyapatna Ian MacFawn Sean Hartwick Sheryl Kunning Cynthia S. Hinck Tullia C. Bruno Adam C. Olson Linda M. McAllister‐Lucas Andrew P. Hinck Kristine Cooper Riyue Bao Anthony R. Cillo Kelly M. Bailey

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Key Points

TGFβ inhibition during radiotherapy enhances immune cell infiltration in tumors and decreases metastases.
The study shows a significant increase in immune cell presence alongside reduced metastatic spread in Ewing sarcoma.
Research employs methods of TGFβ inhibition in conjunction with radiotherapy to assess immune responses.
These findings suggest a potential therapeutic strategy for improving outcomes in Ewing sarcoma patients.

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Implication

Investigation reveals immune cell infiltration increases and metastases decrease in Ewing sarcoma with TGFβ inhibition during radiotherapy.

Abstract

immune cell infiltrates in human tumors

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f8567 https://doi.org/10.1158/2767-9764.29992539

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S2 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
2Figure S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
3Table S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
4Figure S2 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
5Figure S9 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025

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Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
Figure S4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
Figure S14 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025