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August 27, 2025Open Access

Table S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley Elina Mukherjee David Ferraro A. Carolina Tufino Nathanael G. Bailey Shanthi Bhaskar Nivitha Periyapatna Ian MacFawn Sean Hartwick Sheryl Kunning Cynthia S. Hinck Tullia C. Bruno Adam C. Olson Linda M. McAllister‐Lucas Andrew P. Hinck Kristine Cooper Riyue Bao Anthony R. Cillo Kelly M. Bailey

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Key Points

Inhibition of TGFβ during treatment resulted in greater immune cell infiltration into Ewing sarcoma tumors, improving potential outcomes.
The study shows a significant reduction in metastatic spread with TGFβ inhibition during radiotherapy, pointing to its therapeutic promise.
Analysis was based on gene lists from tumor comparisons, providing insights into the molecular mechanisms at play in Ewing sarcoma.
Findings suggest that targeting TGFβ may facilitate improved immune responses against Ewing sarcoma, but further studies are required.

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Implication

Inhibition of TGFβ improves immune cell infiltration and reduces metastases in Ewing sarcoma, suggesting enhanced treatment efficacy.

Abstract

Gene lists from comparisons

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f8771 https://doi.org/10.1158/2767-9764.29992548

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
2Table S2 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
3Figure S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
4Figure S9 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
5Figure S2 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025

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Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
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Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025