Figure S4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley; Elina Mukherjee; David Ferraro; A. Carolina Tufino; Nathanael G. Bailey; Shanthi Bhaskar; Nivitha Periyapatna; Ian MacFawn; Sean Hartwick; Sheryl Kunning; Cynthia S. Hinck; Tullia C. Bruno; Adam C. Olson; Linda M. McAllister‐Lucas; Andrew P. Hinck; Kristine Cooper; Riyue Bao; Anthony R. Cillo; Kelly M. Bailey

doi:10.1158/2767-9764.29992566

Key Points

tgfβ inhibition during radiotherapy reduces the spread of cancer cells in ewing sarcoma.
CT imaging showed significant bony destruction in tumors located in the para-tibial area.
The research utilized mouse tumor models to explore the effects of treatments.
These findings highlight a potential strategy for improving outcomes in ewing sarcoma therapy.

Implication

Ewing sarcoma treatment with tgfβ inhibition enhances immune cell infiltration and decreases metastases, suggesting potential benefits during radiotherapy.

Abstract

Figure S4. CT imaging of mouse tumors demonstrates bony destruction when tumors are established in para-tibial location.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f88ad https://doi.org/10.1158/2767-9764.29992566

View Full Paper

Ask AI

Bookmark

Share

Figure S4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading