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August 27, 2025Open Access

Figure S18 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley Elina Mukherjee David Ferraro A. Carolina Tufino Nathanael G. Bailey Shanthi Bhaskar Nivitha Periyapatna Ian MacFawn Sean Hartwick Sheryl Kunning Cynthia S. Hinck Tullia C. Bruno Adam C. Olson Linda M. McAllister‐Lucas Andrew P. Hinck Kristine Cooper Riyue Bao Anthony R. Cillo Kelly M. Bailey

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Key Points

TGFβ inhibition during radiotherapy led to increased immune cell infiltration in tumors.
Mouse model showed that TGFβ inhibition significantly decreased metastases in Ewing sarcoma.
Analysis of tumor samples utilized histological examination for immune cell quantification.
These findings may advance therapeutic strategies by combining radiotherapy with TGFβ inhibition.

Implication

TGFβ inhibition enhances immune cell infiltration and reduces metastases in Ewing sarcoma, suggesting improved outcomes.

Abstract

Figure S18. Representative H&E images of mouse lungs used for metastatic quantification.

Discussion

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Cite This Study

Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f87e0 https://doi.org/10.1158/2767-9764.29992578

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
2Figure S10 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
3Figure S9 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
4Figure S16 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025
5Figure S8 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma2025