Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma | Synapse
September 10, 2025Open Access
Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Key Points
TGFβ inhibition during radiotherapy significantly increases immune cell infiltration in tumors.
Distinct tumor transcriptional signatures are observed in Ewing sarcomas from different mouse models.
Inhibition leads to decreased metastases, indicating a potential therapeutic strategy.
Study used hu-cD34+ and NSG mouse models to evaluate responses to radiotherapy.
Abstract
Figure S11. Distinct tumor transcriptional signatures following radiation therapy are noted in Ewing sarcomas developed in hu-cD34+ versus NSG mouse models.