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September 17, 2025

Investigation of Glymphatic Biomarkers and Structural Gray Matter Integrity in Cognitive Impairment Using DTI Metrics, DTI-ALPS, and gBOLD-CSF

Key Points

Significant differences in DTI metrics and gBOLD-CSF were found between healthy controls and cognitive impairment patients.
Correlations were observed between DTI metrics and gBOLD-CSF, indicating possible links in glymphatic function.
Examining the relationship between structural gray matter and glymphatic flow can help clarify cognitive decline mechanisms.
These findings emphasize the potential of glymphatic dysfunction as a biomarker for early neurodegeneration.

Abstract

Motivation: The underlying mechanisms of cognitive impairment related to glymphatic clearance based on the structural disruption of GM and glymphatic metrics are required. Goal(s): To understand the relationship between structural changes in the GM, glymphatic flow from DTI-ALPS and gBOLD-CSF inflow metrics to clarify the correlations among CSF circulation, gray matter structural changes, and glymphatic clearance. Approach: Comparing glymphatic-related DTI metrics and global BOLD-CSF inflow between the HC and MCI/AD groups, we also examined the correlation between these metrics. Results: Between the HC and MCI/AD patients, a significant difference in DTI metrics and gBOLD-CSF, and significant correlations between DTI metrics and gBOLD-CSF were observed. Impact: These findings highlight the link between glymphatic dysfunction, CSF circulation, and neurodegeneration, offering clinicians and scientists potential biomarkers for early detection. This study paves the way for further research into therapeutic strategies targeting brain clearance systems to mitigate cognitive decline.

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