What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Linking Brain Reserve to Glymphatic system Function in Mild Cognitive Impairment: Evidenced by Choroid Plexus Volume and DTI-ALPS

Key Points

Glymphatic markers are significantly lower in mild cognitive impairment (MCI) patients, and they correlate with cognitive decline.
Choroid plexus volume and DTI-ALPS were used to reflect glymphatic function and its relationship with cognition.
Cortical atrophy was found to be associated with the reduced glymphatic activity in MCI patients.
These findings imply that glymphatic activity may serve as a potential evaluation marker for brain reserve in MCI.

Abstract

Motivation: Mild cognitive impairment (MCI) patients are often accompanied with gray matter (GM) atrophy and glymphatic impairment, which are associated with cognition Goal(s): To explored how glymphatic function is associated with cortical atrophy and cognitive decline in MCI Approach: We used DTI-ALPS and choroid plexus volume to reflect glymphatic markers. The relationships between glymphatic markers and GM volume and cognition were investigated Results: Our findings revealed that glymphatic markers were significantly lower in MCI, and were associated with GM atrophy and cognition. Impact: Our findings highlight that MCI patients exhibited decreased glymphatic activity compared to NCs, and glymphatic activity could be used to evaluate brain reserve in MCI, which is further related to cognitive impairment

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