Use of primary oral vancomycin prophylaxis to stem an outbreak of Clostridioides difficile infection in intensive care patients

Key Points

• Vancomycin prophylaxis reduced hospital-onset Clostridioides difficile infections significantly to curb an outbreak.
• Infection rates dropped from 19.1 to 5.7 cases per 10,000 patient-days after implementing prophylaxis.
• An observational analysis revealed the impact of primary oral vancomycin prophylaxis on infection rates.
• Further studies may be necessary to evaluate long-term effectiveness and safety of prophylactic treatment.