Oral vancomycin prophylaxis reduced infection rates from 19.1 to 5.7 cases per 10,000 patient-days, suggesting effective outbreak control in intensive care units.
Over 5.5-months, hospital-onset Clostridioides difficile infections (HO-CDI) in intensive care units (ICUs) increased from a baseline 6.2 cases to 19.1 cases per 10,000 patient-days ( P = .03). Primary oral vancomycin prophylaxis (OVP) to select patients was initiated; subsequently there were 5.7 cases /10,000 patient-days ( P = .05). Primary OVP curbed an outbreak of HO-CDI.
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Kewalramani et al. (2025) studied this question.
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