Supplementary Figure 11 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• SPP1+ macrophages lead to CD8 T-cell dysfunction in clear-cell renal cell carcinoma, contributing to immunotherapy resistance.
• Increased absolute expression of SPP1 is observed in macrophage clusters related to tumor activity.
• Analysis highlights the role of tumor-associated macrophages in modulating immune responses, particularly in renal cell carcinoma.
• The findings suggest that targeting macrophage activity may improve outcomes in patients undergoing immunotherapy.