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October 1, 2025

Supplementary Figure 11 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Wenbin Jiang Li Liu Ziyang Xu Youqi Qiu Boyu Zhang Jiangting Cheng Jiyan Luo Yang Qu Jianming Guo Jiejie Xu

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Key Points

SPP1+ macrophages lead to CD8 T-cell dysfunction in clear-cell renal cell carcinoma, contributing to immunotherapy resistance.
Increased absolute expression of SPP1 is observed in macrophage clusters related to tumor activity.
Analysis highlights the role of tumor-associated macrophages in modulating immune responses, particularly in renal cell carcinoma.
The findings suggest that targeting macrophage activity may improve outcomes in patients undergoing immunotherapy.

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Implication

Observational analysis reveals SPP1+ macrophages drive CD8 T-cell dysfunction, suggesting a pathway for immunotherapy resistance.

Abstract

Supplementary Figure 11. Absolute expression of SPP1 in each macrophage cluster.

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Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2199f https://doi.org/10.1158/2326-6066.30255448

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 19 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
2Supplementary Figure 18 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
3Supplementary Figure 12 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
4Supplementary Figure 4 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
5Supplementary Figure 2 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
6Supplementary Figure 15 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
7Supplementary Figure 16 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
8Supplementary Figure 13 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025