October 2, 2025

Supplementary Figure 12 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Discussion

Characterization of SPP1+ tumor-associated macrophages and their role in CD8 T-cell dysfunction.

SPP1+ tumor-associated macrophages drive immunotherapy resistance by impairing CD8 T-cell function, affecting treatment outcomes.
The study identified specific dysfunction in CD8 T-cells associated with SPP1+ TAMs, providing insights into cancer therapy challenges.
Utilizing flow cytometry, the research characterized SPP1+ TAMs to uncover their impact on immune response in tumors.
These findings highlight the need for targeted therapies that overcome macrophage-driven immunotherapy resistance.

Jiang et al. (2025) studied this question.

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