What type of study is this?

This is a Quantitative Study study.

October 2, 2025Open Access

Supplementary Figure 10 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Supplementary figure identifies macrophages driving CD8 T-cell dysfunction in clear-cell renal cancer, indicating resistance to immunotherapy.

Tumor-associated macrophages significantly contribute to immunotherapy resistance in clear-cell renal cell carcinoma.
The study identifies CD8 T-cell dysfunction as a key mechanism via which macrophages exert their effects.
CyTOF technology was used for the identification of macrophages in the tumor microenvironment.
Understanding macrophage roles may lead to improved therapeutic strategies for cancer treatment.

Jiang et al. (2025) studied this question.

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Supplementary figure identifies macrophages driving CD8 T-cell dysfunction in clear-cell renal cancer, indicating resistance to immunotherapy.