October 2, 2025Open Access

Supplementary Figure 13 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Discussion

Supplementary analysis shows CD8 T-cell dysfunction caused by tumor-associated macrophages in clear-cell renal cell carcinoma.

CD8 T-cell dysfunction drives immunotherapy resistance in clear-cell renal cell carcinoma.
Identification of T cells was performed through CyTOF, highlighting significant cellular alterations.
Analysis utilized CyTOF to assess the impact of tumor-associated macrophages on T-cell function.
Findings suggest potential targets for enhancing immunotherapy efficacy in renal cell carcinoma.

Jiang et al. (2025) studied this question.

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